FlyBase Allele Report: Dmel\sc[sisB-3]

General Information

Symbol

Dmel\sc^sisB-3

Species

D. melanogaster

Name

FlyBase ID

FBal0059943

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Wrischnik et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: G172term.

(Wrischnik et al., 2003)

Nonsense mutation just after the bHLH domain.

(Wrischnik et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

sequence_alteration

X:396,690..396,695 [+]

Amino acid change:

G172term | sc-PA

Reported amino acid change:

G172term

Comment:

Approximate location of sc^sisB-3 mutation. Five foreign base pairs are substituted for six endogenous residues beginning at Gly172. The mutation introduces an immediate translation termination codon and a frameshift.

(Wrischnik et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | female | heat sensitive

(Wrischnik et al., 1997)

lethal | female | recessive | heat sensitive

(Wrischnik et al., 2003)

viable | male

(Wrischnik et al., 2003)

visible (with Df(1)sc19)

(Wrischnik et al., 2003)

Phenotype Manifest In

posterior supraalar bristle (with Df(1)sc19)

(Wrischnik et al., 2003)

Detailed Description

Statement

Reference

At 18^oC 94% of expected sc^sisB-2 homozygotes survive to adulthood, but this drops to only 0.3% when these animals are raised at 25^oC. 50-89% of sc^sisB-3/Df(1)sc19 adults lack posterior supraalar bristles.

(Wrischnik et al., 2003)

Little effect on bristle formation.

(Wrischnik et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(1)sc19/sc^sisB-3 has lethal | female | heat sensitive phenotype, suppressible by Sxl^M4/Sxl^M4

(Wrischnik et al., 2003)

Other

Statement

Reference

sc^sisB-3, sisA[+]/sisA¹ has partially lethal - majority die | dominant phenotype

(Wrischnik et al., 2003)

sc[+]/sc^sisB-3, sisA¹ has partially lethal - majority die phenotype

(Wrischnik et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

sc^sisB-3 is a suppressor of macrochaeta | ectopic phenotype of emc²

(Wrischnik et al., 2003)

NOT Suppressor of

Statement

Reference

sc^sisB-3 is a non-suppressor of macrochaeta | ectopic phenotype of hh^bar3

(Wrischnik et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic macrochaetae phenotype in emc²/Df(3L)Ar11 animals is a only weakly suppressed by hemizygous sc^sisB-3.

(Wrischnik et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: Dp(1;1)jnR1-A. Separable from: Dp(1;1)jnR1-A.

(Wrischnik et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sc^sisB-3

sc^sisB3

(González et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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