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General Information
Symbol
Dmel\Hsc70-4D206S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: D206S.

Encodes a Hsc70-4 protein with a single point mutation in the ATP binding site.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Animals expressing Hsc70-4D206S.Scer\UAS under the control of Scer\GAL4337Y die as first or second instar larvae. Animals expressing Hsc70-4D206S.Scer\UAS under the control of Scer\GAL4how-24B generally die as embryos or first instar larvae. Animals expressing Hsc70-4D206S.Scer\UAS under the control of Scer\GAL4how-24B that die as embryos are unable to puncture the egg membrane and hatch and those larvae that do hatch are unable to crawl. Embryos expressing Hsc70-4D206S.Scer\UAS under the control of Scer\GAL4how-24B have a range of severe muscle pattern defects, including gaps in the muscle pattern indicating loss of muscle fibres and irregularities in the muscle pattern. The majority of newly hatched or 2 day old larvae expressing Hsc70-4D206S.Scer\UAS under the control of Scer\GAL4156Y are unable to locate a yeast paste food source within 20 minutes in a behavioural assay.

Dominant lethal allele.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Hsc70-4D206S.Scer\UAS
Hsc70-4D206S.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)