FlyBase Allele Report: Dmel\α-Spec[lm88]

General Information

Symbol

Dmel\α-Spec^lm88

Species

D. melanogaster

Name

FlyBase ID

FBal0062297

Feature type

allele

Associated gene

Dmel\α-Spec

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with α-Spec^rg41)

(Garbe et al., 2007)

abnormal neuroanatomy | recessive

(Garbe et al., 2007)

lethal - all die before end of larval stage | recessive

(Lee et al., 1993)

some die during larval stage | recessive

(Lee et al., 1993)

Phenotype Manifest In

medial longitudinal fascicle | ectopic

(Garbe et al., 2007)

medial longitudinal fascicle | ectopic (with α-Spec^rg41)

(Garbe et al., 2007)

Detailed Description

Statement

Reference

α-Spec^lm88 heterozygotes are viable.

(Ordonez et al., 2018)

α-Spec^lm88 homozygous and α-Spec^rg41/α-Spec^lm88 transheterozygous embryos show mild midline axon guidance defects, with on average less than one medial longitudinal fascicle ectopically crossing the midline per embryo. α-Spec^lm88/+ embryos do not show this defect.

(Garbe et al., 2007)

Rescued to the adult stage by α-Spec^RpS27A.PL.

(Lee et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

α-Spec^lm88 has abnormal neuroanatomy | recessive phenotype, enhanceable by β-Spec^G0198

(Garbe et al., 2007)

Enhancer of

Statement

Reference

α-Spec^lm88 is an enhancer of abnormal neuroanatomy phenotype of β-Spec^G0198

(Garbe et al., 2007)

Other

Statement

Reference

α-Spec^lm88, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has lethal phenotype

(Ordonez et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

α-Spec^lm88 has medial longitudinal fascicle | ectopic phenotype, enhanceable by β-Spec^G0198

(Garbe et al., 2007)

Enhancer of

Statement

Reference

α-Spec^lm88 is an enhancer of medial longitudinal fascicle | ectopic phenotype of β-Spec^G0198

(Garbe et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

β-Spec^G0198/Y; α-Spec^lm88/+ embryos show a mild enhancement of the midline defects seen in β-Spec^G0198/Y embryos. β-Spec^G0198/Y; α-Spec^lm88/α-Spec^lm88 embryos causes an enhancement of the number of times the medial longitudinal fascicle ectopically cross the midline compared to either single mutant.

(Garbe et al., 2007)

Xenogenetic Interactions

Statement

Reference

The expression of Hsap\SNCA^{Ncra\QUAS.cOa} under the control of Ncra\QF^QF2.nSyb in combination with heterozygosity for α-Spec^lm88 leads to lethality.

(Ordonez et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32000

w^*; ru¹ α-Spec^lm88 st¹ e^s/TM6B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

l(3)dre3^lm88

(Lee et al., 1993)

α-Spec^lm88

(Ordonez et al., 2018)

α-spec^lm88

(Hülsmeier et al., 2007)

αSpec^lm88

(Garbe et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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