FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\neb24-O
Open Close
General Information
Symbol
Dmel\neb24-O
Species
D. melanogaster
Name
FlyBase ID
FBal0063850
Feature type
allele
Associated gene
Dmel\neb
Associated Insertion(s)
P{lacW}neb24-O
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Alphey et al., 1997, Molina et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{lacW}neb24-O
Cytology
Description

Insertion of a P{lacW} element within the intron.

(Alphey et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males have no gross meiotic defect in the testes, but motile sperm are not present. Homozygous females have small ovaries with egg chambers rarely developing past stage 5 of oogenesis. There is a failure of follicle cell proliferation, so that larger egg chambers are not completely covered by follicle cells. The egg chambers have the normal number of nurse cells. Homozygous females do not lay eggs. Homozygotes have rough eyes; the facets are of uneven size and shape and many bristles are missing. The array of abdominal bristles is also disrupted in adult homozygotes. Homozygous larval neuroblasts have an increased mitotic index compared to wild-type. Approximately two-thirds of the mitotic figures are polyploid, often having chromosomes arranged on monopolar spindles.

      (Alphey et al., 1997)

      Mitotic chromosome segregation is abnormal, as shown by mitotic figures. The arrangement of chromosomes and centrosomes exhibits a variety of defects.

      (Molina et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      neb24-O is rescued by nebHsp26.PA

      (Alphey et al., 1997)
      Comments

      The sterility of homozygous flies is rescued by nebHsp26.PA.

      (Alphey et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{lacW} element results in complete phenotypic reversion.

      (Alphey et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Klp38B24-O
      neb24-O
      tio24-O
      (Molina et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)