FlyBase Allele Report: Dmel\Sema1a[k03509]

General Information

Symbol

Dmel\Sema1a^k03509

Species

D. melanogaster

Name

FlyBase ID

FBal0064126

Feature type

allele

Associated gene

Dmel\Sema1a

Associated Insertion(s)

P{lacW}Sema1a^k03509

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Yu et al., 1998)

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Sema1a^k03509

Cytology

Description

P{lacW} insertion within a 5kb region upstream of the P{lacW} insertion in Sema-1a^k13702.

(Yu et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Syed et al., 2016)

abnormal neuroanatomy | adult stage (with Sema1a^k13702)

(Syed et al., 2016)

lethal | recessive

(Spradling et al., 1999)

partially lethal - majority die | recessive

(Yu et al., 1998)

Phenotype Manifest In

axon | adult stage

(Syed et al., 2016)

axon | adult stage (with Sema1a^k13702)

(Syed et al., 2016)

motor neuron | adult stage

(Syed et al., 2016)

motor neuron | adult stage (with Sema1a^k13702)

(Syed et al., 2016)

muscle cell of leg muscle of leg

(Syed et al., 2016)

muscle cell of leg muscle of leg (with Sema1a^k13702)

(Syed et al., 2016)

Detailed Description

Statement

Reference

Adult Sema1a^k03509 homozygous mutants as well as Sema1a^k03509/Sema1a^k13702 transheterozygotes display axon mis-projection phenotypes in the leg muscles - lack of innervation of the muscles of the femur and excessive innervation of the muscles of the tibia.

(Syed et al., 2016)

10% of homozygotes survive to adulthood.

(Yu et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(4)C3/+, Sema1a^k03509 has abnormal neuroanatomy | adult stage phenotype

(Syed et al., 2016)

Phenotype Manifest In

Other

Statement

Reference

Df(4)C3/+, Sema1a^k03509 has muscle cell of leg muscle of leg phenotype

(Syed et al., 2016)

Df(4)C3/+, Sema1a^k03509 has motor neuron | adult stage phenotype

(Syed et al., 2016)

Df(4)C3/+, Sema1a^k03509 has axon | adult stage phenotype

(Syed et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Adult Sema1a^k03509/+;Df(4)C3/+ double heterozygotes display axon mis-projection phenotypes in the leg muscles - lack of innervation of the muscles of the femur and excessive innervation of the muscles of the tibia.

(Syed et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: lmg⁰³⁴²⁴. Complements: l(2)rH280^rH280.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

03509

(Yu et al., 1998)

Sema-1a^k03509

Sema1a^P2

(Syed et al., 2016)

Sema1a^k03509

(BDGP Project Members, 1994-1999)

SemaI^P2

(Yu et al., 1998)

l(2)k03509

(Spradling et al., 1999)

l(2)k13702^k03509

sema-1a^P2

(Sweeney et al., 2007)

sema-I^k03509

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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