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General Information
Symbol
Dmel\Rab5k08232
Species
D. melanogaster
Name
FlyBase ID
FBal0064333
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Rab5k08232 is a P-element insertion within the 5' leader coding region of Rab5.

Insertion components
P{lacW}Rab5k08232
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

synaptic vesicle & larval neuromuscular junction

Detailed Description
Statement
Reference

The average number of crystal cells per embryo is reduced (to 11.4) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average).

Homozygous Rab5k08232 animals die during late second and early third instar larval stages with only a light locomotion phenotype. Consistent with a mild phenotype, both synaptic uptake and transmission rates to the muscles are normal. If raised under `intensive care' conditions, very few Rab5k08232 larvae develop into adult flies, which display a flightless phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

There is no significant difference in the nervous system degeneration seen in SNF4Aγloe mutants in a Rab5k08230 heterozygous background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The Rab5k08232 lethality and phenotype are caused by reduced Rab5 levels in the nervous system as they can be rescued by restricted expression of Rab5Scer\UAS.T:Avic\GFP-EGFP, under the regulation of Scer\GAL4elav-C155 in the nervous system. Rab5+tWa rescues the lethality due to Rab5k08232.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Lethality can be reverted by precise excision P{lacW}Rab5k08232.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)