FlyBase Allele Report: Dmel\porin[k05123]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\porin^k05123

General Information

Symbol

Dmel\porin^k05123

Species

D. melanogaster

Name

FlyBase ID

FBal0064511

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}porin^k05123

Carried in Construct

Also Known As

l(2)k05123

Key Links

Genomic Maps

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}porin^k05123

Cytology

Description

P{lacW} insertion in the first intron.

(Oliva et al., 2002)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:10,850,344..10,850,344 [-]

(Khalil et al., 2015, Oliva et al., 2002, Mesilaty-Gross et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of retinal degeneration

CEA

(Huang et al., 2015)

model of Huntington's disease

CEC with Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018, Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior (with porin^k08405)

(Oliva et al., 2002)

abnormal locomotor behavior | recessive

(Oliva et al., 2002)

abnormal neurophysiology | adult stage | somatic clone

(Huang et al., 2015)

increased cell death | adult stage | progressive | somatic clone

(Huang et al., 2015)

lethal (with porin^1rev6)

(Oliva et al., 2002)

lethal (with porin^1rev17)

(Oliva et al., 2002)

lethal (with porin^1rev23)

(Oliva et al., 2002)

lethal (with porin^2rev8)

(Oliva et al., 2002)

lethal (with porin^k08405)

(Oliva et al., 2002)

lethal | recessive

(Oliva et al., 2002, Spradling et al., 1999, BDGP Project Members, 1994-1999)

male fertile (with porin^1rev2)

(Oliva et al., 2002)

male fertile (with porin^1rev16)

(Oliva et al., 2002)

male fertile (with porin^1rev18)

(Oliva et al., 2002)

male fertile (with porin^1rev21)

(Oliva et al., 2002)

male fertile (with porin^2rev2)

(Oliva et al., 2002)

male fertile (with porin^2rev3)

(Oliva et al., 2002)

male fertile (with porin^2rev7)

(Oliva et al., 2002)

male fertile (with porin^2rev14)

(Oliva et al., 2002)

male sterile (with porin^2rev9)

(Oliva et al., 2002)

short lived (with porin^k08405)

(Oliva et al., 2002)

short lived | recessive

(Oliva et al., 2002)

Phenotype Manifest In

eye | somatic clone

(Huang et al., 2015)

eye photoreceptor cell | somatic clone

(Huang et al., 2015)

retina | somatic clone

(Huang et al., 2015)

rhabdomere of eye photoreceptor cell | somatic clone

(Huang et al., 2015)

Detailed Description

Statement

Reference

porin^k05123 homozygous mutant clones in the eye have normal morphology at 1 day old and then show light-dependent retinal degeneration (at 10 days old, including loss of rhabdomeres), and ERG recordings show slow termination of the light response compared to wild type; remobilization of the porin^k05123 P-element rescues the phenotype.

(Huang et al., 2015)

Rare adult homozygous escapers are seen. Homozygous and porin^k05123/porin^k08405 adult escapers do not show any evident morphological defects, but have locomotory abnormalities and a short life span.

(Oliva et al., 2002)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, porin[+]/porin^k05123 has short lived phenotype, non-suppressible by Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Suppressor of

Statement

Reference

porin^k05123 is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

porin^k05123 is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in the presence of heterozygous porin^k05123 fails to extend lifespan or suppress neuronal loss in flies also expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Khalil et al., 2015)

Complementation and Rescue Data

Fails to complement

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

10563

y¹ w^67c23; P{lacW}porin^k05123/CyO

111174

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}porin^k05123 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Comments

Complements: l(2)k09015a^k09015a. Complements: UbcD2^k13206.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

k05123

(Kaltenbach et al., 2007)

l(2)k05123

(Oliva et al., 2002, Mesilaty-Gross et al., 1999, Spradling et al., 1999)

l(2)k05123^k05123

(BDGP Project Members, 1994-1999)

porin¹

(Oliva et al., 2002)

porin^k05123

(Kanellopoulos et al., 2020, Al-Ramahi et al., 2018, Huang et al., 2015, Khalil et al., 2015, Christensen and Cook, 2006.12.5)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections