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General Information
Symbol
Dmel\srb.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0065677
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

An EcoRI/XbaI fragment of the sr b cDNA (nucleotides 405 to 4458) is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of srb.Scer\UAS under the control of Scer\GAL4sr-md710 results in a severe decrease in the number of microchaetae on the notum. Expression of srb.Scer\UAS under the control of Scer\GAL4sca-C253 results in a total lack of bristles on the notum.

Expression of srb.Scer\UAS in the developing mesoderm using Scer\GAL4how-24B does not cause muscle defects. Expression of srb.Scer\UAS in the ventral midline using Scer\GAL4sim.PS results in strong distortion of the ventral muscles, which frequently cross the midline. Expression of srb.Scer\UAS using Scer\GAL4en-e16E produces a disturbed muscle pattern, and lateral transverse muscles with abnormally elongated processes are seen. Expression of srb.Scer\UAS using Scer\GAL4ptc-559.1 produces a disturbed muscle pattern, and fused myotubes of abnormal shape are seen. Expression of srb.Scer\UAS using Scer\GAL4h.6 results in the absence of ventral longitudinal and lateral transversal muscles in abdominal segments 5 to 7. Ubiquitous expression of srb.Scer\UAS using Scer\GAL4hs.2sev results in an abnormal muscle pattern only when expression occurs prior to embryonic stage 15. When expressed at stage 12 using Scer\GAL4hs.2sev, abnormal outgrowth of muscles is seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

srb.UAS/Scer\GAL4sca-C253 is a suppressor of mesothoracic tergum & macrochaeta | ectopic phenotype of Scer\GAL4sca-C253, scUAS.cHa

Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of srb.Scer\UAS removes most of the ectopic bristles on the notum caused by expression of scScer\UAS.cHa under the control of Scer\GAL4sca-C253 and also removes many of the extant ones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
srb.Scer\UAS
srb.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)