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Citation
Vorbruggen, G., Jackle, H. (1997). Epidermal muscle attachment site-specific target gene expression and interference with myotube guidance in response to ectopic stripe expression in the developing Drosophila epidermis.  Proc. Natl. Acad. Sci. U.S.A. 94(16): 8606--8611.
FlyBase ID
FBrf0097704
Publication Type
Research paper
Abstract

The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal cells to which muscles attach during late stages of embryogenesis. We report loss-of-function and gain-of-function experiments indicating that sr activity provides ectodermal cells with properties required for the establishment of a normal muscle pattern during embryogenesis and for the differentiation of tendon-like epidermal muscle attachment sites (EMA). Our results show that sr encodes a transcriptional activator which acts as an autoregulated developmental switch gene. sr activity controls the expression of EMA-specific target genes in cells of ectodermal but not of mesodermal origin. sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of the elongating myotubes.

PubMed ID
PubMed Central ID
PMC23040 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
  • FBrf0098112
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Proc. Natl. Acad. Sci. U.S.A.
Title
Proceedings of the National Academy of Sciences of the United States of America
Publication Year
1915-
ISBN/ISSN
0027-8424
Data From Reference
Alleles (9)
Genes (10)
Insertions (3)
Experimental Tools (2)
Transgenic Constructs (5)