FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nej1
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General Information
Symbol
Dmel\nej1
Species
D. melanogaster
Name
FlyBase ID
FBal0065728
Feature type
allele
Associated gene
Dmel\nej
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Most nej1 hemizygotes develop to the end of embryogenesis and are phenotypically wild type. Approximately 13% of the embryos have head defects and 4.5% have fusions of the segmental denticle belts, primarily between the denticle belts of the fourth and the fifth abdominal segments.

        (Bantignies et al., 2002)

        Embryos derived from homozygous females show loss of the amnioserosa and other derivatives of the dorsal ectoderm.

        (Ashe et al., 2000)

        In mutant embryos derived from mutant female germlines the midgut phenotypes range from mild to severe.

        (Waltzer and Bienz, 1998)

        Fertile eggs are produced from germ line clones. Paternally rescued eggs exhibit narrowing of the head and thorax regions and lack epidermal structures in the dorsal and ventral regions.

        (Akimaru et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        nej1 is an enhancer of melanotic mass phenotype phenotype of krzL8

        (Bantignies et al., 2002)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Fifteen percent (73 of 487) of nej1 hemizysgous; Df(3R)A4-4L8 homozygous embryos have fusions of the segmental denticle belts. These fusions occur between the second and the third, the third and the fourth, or the fourth and the fifth abdominal segments. 24.2% (118 of 487) of these embryos have head defects. This percentage suggests an additive effect on embryonic head development.

        (Bantignies et al., 2002)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        nej1
        (Li et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (10)