FlyBase Allele Report: Dmel\krz[L8]

General Information

Symbol

Dmel\krz^L8

Species

D. melanogaster

Name

FlyBase ID

FBal0118175

Feature type

allele

Associated gene

Dmel\krz

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

Df(3R)A4-4L8

Cytology

Description

Approximately 24kb deletion with one breakpoint in the P{wA}4-4 element and the proximal breakpoint 47bp 5' of the longest krz cDNA detected.

(Roman et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Roman et al., 2000)

melanotic mass phenotype

(Bantignies et al., 2002)

melanotic mass phenotype | larval stage | recessive

(Roman et al., 2000)

Phenotype Manifest In

embryonic/larval fat body

(Roman et al., 2000)

melanotic mass | ectopic

(Roman et al., 2000)

Detailed Description

Statement

Reference

As third instar larvae krz^L8 homozygotes develop melanotic tumors. This phenotype is incompletely penetrant and has variable expressivity.

(Bantignies et al., 2002)

Third instar larvae develop melanotic tumours, which form throughout the body cavity but most frequently collect in the posterior of the larva. Tumours are frequently found floating free in the haemocoel. Some disaggregation of the fat body is seen.

(Roman et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

krz^L8 has melanotic mass phenotype phenotype, enhanceable by nej³

(Bantignies et al., 2002)

krz^L8 has melanotic mass phenotype phenotype, enhanceable by nej¹

(Bantignies et al., 2002)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Both the penetrance and expressivity of the melanotic tumor phenotype seen in third instar krz^L8/krz^L8 larvae, are significantly enhanced by heterozygosity for nej¹ or nej³.

(Bantignies et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

krz⁴

(Roman et al., 2000)

Fails to complement

krz³

(Roman et al., 2000)

krz^S047819

(Roman et al., 2000)

krz^S095214

(Roman et al., 2000)

Partially rescued by

krz^L8 is partially rescued by krz^+t5.8

(Roman et al., 2000)

Comments

krz^+t5.8 rescues the larval lethality and formation of melanotic tumours seen in krz^L8 animals.

(Roman et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

krz^L8

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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