FlyBase Allele Report: Dmel\Dad[271-68]

General Information

Symbol

Dmel\Dad^271-68

Species

D. melanogaster

Name

FlyBase ID

FBal0066215

Feature type

allele

Associated gene

Dmel\Dad

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Tsuneizumi et al., 1997)

Progenitor genotype

P{lacW}Dad^j1E4

(Horsfield et al., 1998, Tsuneizumi et al., 1997)

Cytology

Description

Deletion of entire C-terminal domain after amino acid 391.

(Tsuneizumi et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates childhood spinal muscular atrophy

modeled by Smn^73Ao, Smn^f01109

(Chang et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Dad^j1E4)

(O'Connor-Giles et al., 2008)

abnormal neuroanatomy | recessive

(Sweeney and Davis, 2002)

abnormal neuroanatomy | third instar larval stage

(Chang et al., 2008)

Phenotype Manifest In

bouton | increased number

(Sweeney and Davis, 2002)

female germline stem cell

(Xie and Spradling, 1998)

neuromuscular junction

(Sweeney and Davis, 2002)

NMJ bouton

(Chang et al., 2008)

NMJ bouton | larval stage | increased number (with Dad^j1E4)

(O'Connor-Giles et al., 2008)

wing vein

(Liu et al., 2011)

wing vein | ectopic

(Liu et al., 2011)

Detailed Description

Statement

Reference

Homozygotes display a modest broadening of existing veins and the formation of extra veins in the wing.

(Liu et al., 2011)

Homozygous third instar larvae show a slight reduction in bouton number per muscle area at the neuromuscular junction compared to wild type.

(Chang et al., 2008)

Dad^j1E4/Dad^271-68 larvae show an increase in both the total number of boutons and the number of satellite boutons at the neuromuscular junction compared to wild type.

(O'Connor-Giles et al., 2008)

Dad^271-68 does not protect Df(1)su(s)R194/+ clones in the eye; Df(1)su(s)R194/+ ; Dad^271-68 clones are not recovered in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals).

(Tyler et al., 2007)

Homozygous and Dad^271-68/Dad^j1E4 larvae show no significant change in the number of synaptic boutons at the neuromuscular junction.

(McCabe et al., 2004)

Homozygous larvae have synapses with dramatically altered morphology at the neuromuscular junction. There are increased numbers of distinct, small boutons that sprout from what appear to be the normal synaptic process. This phenotype is highly penetrant and is observed at muscles 6/7 and muscle 4. The number of boutons is significantly increased compared to wild type.

(Sweeney and Davis, 2002)

Clonal analysis in the germarium reveals that mutant stem cells are not lost. No turnover was detected even after three weeks, suggesting prologued stem cell life. Stem cell division rate relative to control is 0.84. Cysts contain the normal 16 cells, including and oocyte.

(Xie and Spradling, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dad^271-68/Dad^271-68 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Smn^73Ao

(Chang et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dad^271-68/Dad[+] is an enhancer of wing vein phenotype of Ctdnep1^G0269

(Liu et al., 2011)

Dad^271-68 is an enhancer of phenotype of CycE^JP

(Horsfield et al., 1998)

Suppressor of

Statement

Reference

Dad^271-68/Dad^271-68 is a suppressor of NMJ bouton phenotype of Smn^73Ao

(Chang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The aberrant wing vein phenotype seen in Dd^G0269/Y animals is enhanced by Dad^271-68/+.

(Liu et al., 2011)

The reduction in bouton number per muscle area at the neuromuscular junction that is seen in Smn^73Ao/Smn^f01109 third instar larvae is suppressed by Dad^271-68/Dad^271-68.

(Chang et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dad^1E4(271-68)

(Henderson et al., 1999)

Dad^271-68

(Liu et al., 2011, Chang et al., 2008, O'Connor-Giles et al., 2008, Tyler et al., 2007, Xie and Spradling, 1998)

dad^271-68

(Sweeney and Davis, 2002)

dad^Δ1E427-68

(Horsfield et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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