FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctdnep1G0269
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General Information
Symbol
Dmel\Ctdnep1G0269
Species
D. melanogaster
Name
FlyBase ID
FBal0102645
Feature type
allele
Associated gene
Dmel\Ctdnep1
Associated Insertion(s)
P{lacW}Ctdnep1G0269
Carried in Construct
Also Known As
dddP
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Liu et al., 2011)
Mutagen
P-element activity
(Schäfer et al., 1999.12.14)
Progenitor genotype
Associated Insertion(s)
P{lacW}Ctdnep1G0269
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ427034
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DdG0269 embryonic lethality is 42%, pupal lethality is 76%, and lethality of larvae is lower.

      DdG0269 mutants show abnormal wing vein morphology at 99% penetrance. 38% of wings exhibit extra cross veins located in the region between L2 and L5 and a broadening of L2, L3 veins and the original anterior and posterior crossveins. This broadening of wing veins alone is observed in an additional 61% of wings.

      (Liu et al., 2011)

      Mutants have small wings.

      (Peter et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Ctdnep1G0269 has wing vein phenotype, enhanceable by Dad271-68/Dad[+]

      (Liu et al., 2011)
      Suppressed by
      Statement
      Reference

      Ctdnep1G0269 has wing vein phenotype, suppressible by Mad12/Mad[+]

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by tkv7/tkv[+]

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by sax4/sax[+]

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by put[+]/put10460

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by dpphr56/dpp[+]

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by Scer\GAL4Act.PU/DadUAS.cTa

      (Liu et al., 2011)

      Ctdnep1G0269 has wing vein phenotype, suppressible by LpinEP2431/Scer\GAL4hs.PU

      (Liu et al., 2011)
      Other
      Statement
      Reference

      Ctdnep1G0269, ciD has wing vein phenotype

      (Liu et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The aberrant wing vein phenotype seen in DdG0269/Y animals is suppressed by Mad12/+, tkv7/+, sax4/+, put10460/+, or dpphr56/+.

      The aberrant wing vein phenotype seen in DdG0269/Y animals is enhanced by Dad271-68/+.

      Scer\GAL4Act.PU-mediated expression of DadScer\UAS.cTa completely rescues the vein phenotype of DdG0269/Y.

      DdG0269/Y; ciD/+ wings show a combination of the disrupted wing vein phenotype of ciD/+ and the extra vein phenotype of DdG0269 in an additive manner.

      Scer\GAL4hs.PU-mediated expression of LpinEP2431 rescues the abnormal vein phenotypes of DdG0269/Y.

      (Liu et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ctdnep1G0269 is rescued by Ctdnep1UAS.cLa/Scer\GAL4hs.PU

      (Liu et al., 2011)

      Ctdnep1G0269 is rescued by Ctdnep1UAS.Tag:HA/Scer\GAL4hs.PU

      (Liu et al., 2011)
      Comments

      Scer\GAL4hs.PU-mediated expression of DdScer\UAS.cLa or DdScer\UAS.T:Ivir\HA1 rescues the abnormal vein phenotypes of DdG0269.

      (Liu et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.12.14)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Ctdnep1G0269
      DdG0269
      dddP
      (Liu et al., 2011)
      dddp
      (Sardi et al., 2021)
      l(1)G0269
      (Peter et al., 2002)
      l(1)G0269G0269
      Name Synonyms
      Secondary FlyBase IDs
        References (4)