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General Information
Symbol
Dmel\shiCK2
Species
D. melanogaster
Name
FlyBase ID
FBal0082267
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    100% of shiCK2 flies completely paralyse within about 2 minutes at 35oC. At 33oC, no shiCK2 flies are paralysed within 3 minutes. The on- and off-transients of the electroretinogram (ERG) are lost at 36oC in shiCK2/Y flies.

    Mutant flies are paralysed at 35oC. At 36oC the on- and off-transients normally seen in an electroretinogram are lost. At 31oC shiCK2 flies show characteristic recycling intermediates (deep membrane invaginations) in the photoreceptor terminals in the lamina.

    Sub-anaesthetic concentration of carbon dioxide specifically suppresses the temperature sensitive paralytic phenotype.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    shiCK2 has abnormal neurophysiology | heat sensitive phenotype, enhanceable by sesBorg

    shiCK2 has paralytic | heat sensitive phenotype, enhanceable by awdMSM95

    shiCK2 has paralytic | heat sensitive phenotype, enhanceable by sesBorg/sesBorg

    shiCK2 has paralytic | heat sensitive phenotype, enhanceable by awdCM47

    shiCK2 has paralytic | heat sensitive phenotype, enhanceable by awdMSF15

    shiCK2 has paralytic | heat sensitive phenotype, enhanceable by awdMSM95/awdKRS6

    NOT Enhanced by
    Statement
    Reference

    shiCK2 has paralytic | heat sensitive phenotype, non-enhanceable by awdK/awdK

    Phenotype Manifest In
    Enhanced by
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    sesBorg lowers the temperature at which 100% of shiCK2 flies are paralysed in 3 minutes, from 35oC to 33oC. 100% of shiCK2 ; awdMSM95/awdMSM95 flies are paralysed in 3 minutes at 29oC. 100% of sesBorg shiCK2 ; awdMSM95/awdMSM95 flies are paralysed in 3 minutes at 27oC. The on- and off-transients of the electroretinogram (ERG) are lost at 33oC in sesBorg shiCK2/Y flies. The on- and off-transients of the electroretinogram (ERG) are lost at 27oC in sesBorg shiCK2/Y ; awdMSM95/awdMSM95 flies.

    The temperature at which 100% of shiCK2 flies are paralysed is reduced if they also carry awdMSM95, awdCM47 or awdMSF15. The temperature at which the ERG on- and off-transients are lost is lowered to 30oC in shiCK2 flies that also carry awdMSM95/awdKRS6. The temperature at which the membrane invaginations are seen in the photoreceptor terminals in the lamina in shiCK2 flies is reduced if they are also carrying awdMSM95/awdKRS6. shiCK2/Y ; awdMSM95/awdKRS6 motor terminals show reduced uptake of an endocytosis tracer at 38oC compared to controls. The general morphology of the motor nerve endings appears normal in these flies.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (5)