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General Information
Symbol
Dmel\kuzH143
Species
D. melanogaster
Name
FlyBase ID
FBal0082860
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    kuzH143 mutants exhibit thinning of the longitudinal connectives and thickening of the commissures compared to controls. 50% of the segments examined in kuzH143 homozygous mutants display FasII axon crossing defects. No FasII axon crossing defects are seen in kuzH143/+. However kuzH143 heterozygotes do exhibit mild ectopic ap neuron crossing.

    Homozygous clones induced in the thorax at 48-72 hours after egg laying are missing macrochaetae and microchaetae, and a tuft of macrochaetae develops in the area devoid of bristles. Homozygous clones induced in the dorsal part of the wing at 48-72 hours after egg laying give rise to thickening of the wing veins and nicks at the wing margin.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference
    Enhancer of
    Statement
    Reference
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    kuzH143 has commissure | embryonic stage 16 phenotype, enhanceable by sli2/sli[+]

    kuzH143 has commissure | embryonic stage 16 phenotype, enhanceable by robo[+]/sli[+]/robo15/sli1

    Enhancer of
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    One copy each of sli1 and robo5 enhances the FasII axon midline crossing phenotype seen in kuzH143 stage 16 embryos.

    A kuzH143 background enhances the FasII midline crossing phenotype seen in sli1, robo5 transheterozygous stage 16 embryos.

    kuzH143, sli2 transheterozygous stage 16 embryos display a stronger ectopic ap neuron crossing phenotype than either mutant alone.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (3)