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General Information
Symbol
Dmel\kuzk01405
Species
D. melanogaster
Name
FlyBase ID
FBal0082859
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
kuz1405
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{lacW} element within untranslated leader sequences.

Insertion components
P{lacW}kuzk01405
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

kuzk01405 germ line clones exhibit duplication of the RP2 neurons.

Homozygotes have severely reduced wings and halteres, small nota, shortened legs with fused tarsal segments and rough eyes. The flies have gross alterations in the pattern of sensory organs, including the appearance of abnormal tufts of bristles or other sensory organs in locations where only one sensory organ or naked cuticle is present in wild-type flies. Cuticle lacking both microchaetae and macrochaetae is also seen. Homozygous clones induced in the dorsal part of the wing at 60-84 hours after egg laying give rise to thickening of the wing veins and nicks at the wing margin. Within the clone a cluster of campaniform sensilla develops at the position of one of the twin sensilla of the margin. kuz1405Rev4/kuzk01405 flies show scalloping of the wings. Homozygous larvae have imaginal discs of reduced size. The pupal notum contains lawns of neurons where only one or a few neurons are present in wild-type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

kuzk01405 is a suppressor | partially of visible phenotype of H2

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

kuzk01405 has leg phenotype, suppressible by Nint.hs

kuzk01405 has eye phenotype, suppressible by Nint.hs

kuzk01405 has wing phenotype, suppressible by H2

kuzk01405 has wing phenotype, suppressible by Nint.hs

kuzk01405 has haltere phenotype, suppressible by Nint.hs

Enhancer of
Statement
Reference

kuzk01405/kuz1405Rev4 is an enhancer of wing phenotype of SerD

Suppressor of
Statement
Reference

kuzk01405 is a suppressor of sense organ phenotype of H2

NOT Suppressor of
Statement
Reference

kuzk01405 is a non-suppressor of wing vein phenotype of H2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The scalloping of the wing margin seen in SerD/+ heterozygotes is enhanced if the flies also carry kuz1405Rev4/kuzk01405. The neurogenic phenotype of kuzk01405 flies is partially rescued by E(spl)Scer\UAS.cSa expressed under the control of Scer\GAL4C-765; many single sensory organs, rather than tufts of sensory organs, develop on the notum. The sensory organ but not the wing vein phenotypes of H2 heterozygotes and homozygotes are suppressed by kuzk01405. The neurogenic phenotype and reduced wing size of kuzk01405 homozygotes is suppressed by H2. kuzk01405 is partially rescued by Nint.hs at 25oC; kuzk01405 flies carrying Nint.hs have a normal-sized notum and eyes, and their legs, wings and halteres are substantially larger than those of kuzk01405 single mutant flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Partially rescued by
Comments

The development of wings, halteres, thorax, legs and eyes in homozygotes is rescued by kuzScer\UAS.cFa expressed under the control of Scer\GAL4C-765. The pattern of sensory organs is restored almost to normal in these flies, although several notum microchaetae are missing and extra stout bristles (some with abnormal morphology) are seen on the anterior wing margin.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

May be a cluster mate of kuzk01403.

Comments
Comments

Precise excision of the P{lacW} element results in reversion to wild-type.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)