FB2026_02 , released June 18, 2026
Allele: Dmel\EcRC300Y
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General Information
Symbol
Dmel\EcRC300Y
Species
D. melanogaster
Name
FlyBase ID
FBal0083496
Feature type
allele
Associated gene
Dmel\EcR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Bender et al., 1997)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Mutation is in the DNA-binding domain (numbering with respect to the EcR-B1 open reading frame).

    (Bender et al., 1997)

    Nucleotide substitution: G?A.

    (Bender et al., 1997)

    Amino acid replacement: C300Y.

    (Bender et al., 1997)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:6,094,852..6,094,852 [-]
    Nucleotide change:

    G6094852A

    Reported nucleotide change:

    G?A

    Amino acid change:

    C271Y | EcR-PA; C300Y | EcR-PB; C91Y | EcR-PC; C271Y | EcR-PD; C271Y | EcR-PE; C300Y | EcR-PG

    Reported amino acid change:

    C300Y

    (Bender et al., 1997)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Trained heterozygous EcRC300Y mutant males display normal courtship short-term memory in behavioural assays, but are defective in long-term memory.

        (Ishimoto et al., 2009)

        EcRC300Y heterozygous adults exhibit a significant increase in lifespan as compared o controls.

        (Simon et al., 2003)

        Heterozygotes are phenotypically wild type.

        (Arbeitman and Hogness, 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        EcRC300Y is an enhancer of wing phenotype of mys8

        (D'Avino and Thummel, 2000)

        EcRC300Y is an enhancer of wing phenotype of if3

        (D'Avino and Thummel, 2000)
        Other
        Statement
        Reference

        EcRC300Y, Hsc70-4195/Hsc70-4[+] has wing phenotype

        (Arbeitman and Hogness, 2000)

        EcRC300Y, Hsc70-4195/Hsc70-4[+] has leg phenotype

        (Arbeitman and Hogness, 2000)

        EcRC300Y/EcR[+], Hsc70-4195 has wing phenotype

        (Arbeitman and Hogness, 2000)

        EcRC300Y/EcR[+], Hsc70-4195 has leg phenotype

        (Arbeitman and Hogness, 2000)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        In transheterozygous combination with Hsc70-4195, wings are frequently blistered and legs are occasionally malformed. This enhancement is completely suppressed by P{Hsc70-4.14}.

        (Arbeitman and Hogness, 2000)

        EcRC300Y/Sin3A08269 transheterozygotes show normal viability and no visible phenotype.

        (Bodai, 2000.12.22)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        EcRC300Y
        (Ishimoto et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)