FlyBase Allele Report: Dmel\Dhc64C[ek1]

General Information

Symbol

Dmel\Dhc64C^ek1

Species

D. melanogaster

Name

enhancer of kinesin 1

FlyBase ID

FBal0086877

Feature type

allele

Associated gene

Dmel\Dhc64C

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Martin et al., 1999)

Mutagen

ethyl methanesulfonate

(Martin et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Martin et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dhc64C^ek1 is a suppressor of paralytic | posterior | larval stage phenotype of Aplip1^EK4

(Horiuchi et al., 2005)

Other

Statement

Reference

Dhc64C[+]/Dhc64C^ek1, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Dhc64C[+]/Dhc64C^ek1, Klc^unspecified has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Dhc64C^ek1, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Dhc64C^ek1, Klc^unspecified/Klc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dhc64C[+]/Dhc64C^ek1 is an enhancer of posterior fascicle & axon phenotype of Khc¹⁶

(Martin et al., 1999)

Dhc64C[+]/Dhc64C^ek1 is an enhancer of phenotype of Khc^unspecified

(Martin et al., 1997)

Suppressor of

Statement

Reference

Dhc64C^ek1 is a suppressor of axon phenotype of Aplip1^EK4

(Horiuchi et al., 2005)

Other

Statement

Reference

DCTN1-p150^Gl-1, Dhc64C[+]/Dhc64C^ek1 has posterior fascicle & axon phenotype

(Martin et al., 1999)

Dhc64C[+]/Dhc64C^ek1, Klc^unspecified has posterior fascicle & axon phenotype

(Martin et al., 1999)

Dhc64C^ek1, Klc^unspecified/Klc[+] has posterior fascicle & axon phenotype

(Martin et al., 1999)

Gl[+]/DCTN1-p150^Gl-1, Dhc64C^ek1 has posterior fascicle & axon phenotype

(Martin et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Dhc64C^ek1, Aplip1^EK4 larvae show lower levels of posterior paralysis and axonal swelling than Aplip1^EK4 larvae.

(Horiuchi et al., 2005)

Dhc64C^ek1 Khc¹⁶ double heterozygous larvae show a posterior paralysis phenotype. Dhc64C^ek1 Gl¹ double heterozygous larvae do not show a posterior paralysis phenotype. Some axonal swellings are seen in the segmental nerves of heterozygous Khc¹⁶ larvae. The number of axonal swellings is dramatically increased if the larvae are also heterozygous for Dhc64C^ek1. The axon swellings seen in double heterozygotes are rescued by Khc^+t7.5. A slight increase in the number of axonal swellings in the segmental nerves is seen in Dhc64C^ek1/+ ; Gl¹/+ double heterozygous larvae compared to single heterozygotes. Dhc64C^ek1 Klc^unspecified double heterozygous larvae show a posterior paralysis phenotype. Large axon swellings are seen.

(Martin et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Severe mutation.

(Martin et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dhc64C^ek1

(Martin et al., 2005)

E(Khc)ek1

(Martin et al., 1999, Martin et al., 1997)

cDhc64C^ek1

(Horiuchi et al., 2005)

Name Synonyms

enhancer of kinesin 1

(Martin et al., 1997)

Secondary FlyBase IDs

References (4)

Report Sections

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