FlyBase Allele Report: Dmel\Khc[16]

General Information

Symbol

Dmel\Khc¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0044868

Feature type

allele

Associated gene

Dmel\Khc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Martin et al., 1996)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior (with Dp(1;2;Y)w⁺)

(Gindhart et al., 2003)

Phenotype Manifest In

axon (with Dp(1;2;Y)w⁺)

(Gindhart et al., 2003)

axon (with Tp(1;3)w^vco)

(Gindhart et al., 2003)

posterior fascicle & axon

(Martin et al., 1999)

Detailed Description

Statement

Reference

Khc¹⁶/+; Dp(1;2;Y)w⁺/+ larvae display strong axon clog and locomotion phenotypes, while Khc¹⁶/+; Tp(1;3)w^vco/+ larvae display only the axon clog phenotype.

(Gindhart et al., 2003)

Heterozygous larvae show normal locomotion. Some axonal swellings are seen in the segmental nerves of heterozygous larvae.

(Martin et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Abl¹/Abl[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype, suppressible by ena[+]/ena²¹⁰

(Martin et al., 2005)

Abl¹/Abl[+], Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype, suppressible by ena[+]/ena²¹⁰

(Martin et al., 2005)

Other

Statement

Reference

Df(3L)81k19/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)81k19/+, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)tra/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)tra/+, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)st-b11/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)st-b11/+, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)st-E36/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

Df(3L)st-E36/+, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

+/Df(3L)st-j7, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

+/Df(3L)st-j7, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

In(3L)std11/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

In(3L)std11/+, Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

Abl¹/Abl[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 2005)

Abl¹/Abl[+], Khc¹⁶ has abnormal neuroanatomy | dominant | larval stage phenotype

(Martin et al., 2005)

Aplip1^EK4, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

DCTN1-p150^Gl-1, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek8[+]/E(Khc)ek8^ek8, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek9^ek9/E(Khc)ek9[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Gl[+]/DCTN1-p150^Gl-1, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Df(3L)34ex5/+, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Dhc64C[+]/Dhc64C^ek1, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek10[+]/E(Khc)ek10^ek10, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Dhc64C^ek1, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek9^ek9, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek2^ek2, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek10^ek10, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek5^ek5, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek2^ek2/E(Khc)ek2[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek7^ek7, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek8^ek8, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek3^ek3, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek6^ek6, Khc¹⁶/Khc[+] has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek3^ek3/E(Khc)ek3[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Aplip1^EK4/Aplip1[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek5[+]/E(Khc)ek5^ek5, Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek6^ek6/E(Khc)ek6[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

E(Khc)ek7^ek7/E(Khc)ek7[+], Khc¹⁶ has paralytic | dominant | larval stage phenotype

(Martin et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Khc¹⁶ has posterior fascicle & axon phenotype, enhanceable by Dhc64C[+]/Dhc64C^ek1

(Martin et al., 1999)

Khc¹⁶ has posterior fascicle & axon phenotype, enhanceable by Gl[+]/DCTN1-p150^Gl-1

(Martin et al., 1999)

Khc¹⁶ has posterior fascicle & axon phenotype, enhanceable by Df(3L)34ex5/+

(Martin et al., 1999)

Suppressed by

Statement

Reference

Abl¹/Abl[+], Khc¹⁶ has axon phenotype, suppressible by ena[+]/ena²¹⁰

(Martin et al., 2005)

Other

Statement

Reference

Df(3L)81k19/+, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

Df(3L)tra/+, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

Df(3L)st-b11/+, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

Df(3L)st-E36/+, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

In(3L)std11/+, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

Abl¹/Abl[+], Khc¹⁶ has axon phenotype

(Martin et al., 2005)

+/Df(3L)st-j7, Khc¹⁶ has axon phenotype

(Martin et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Khc¹⁶/+ larvae that are also heterozygous for one of Df(3L)81k19, Df(3L)tra, Df(3L)st-b11, Df(3L)st-E36, Df(3L)st-j7 or In(3L)std11 develop numerous large axonal swellings and show paralytic tail flipping.

Khc¹⁶/+ ; Abl¹/+ double heterozygous larvae show posterior paralysis or "tail-flipping" and show an increase in the size and abundance of axonal swellings.

Khc¹⁶/ena²¹⁰ ; Abl¹/+ triple heterozygous larvae do not show a tail-flipping phenotype and there is a marked reduction in axonal swellings compared to Khc¹⁶/+ ; Abl¹/+ double heterozygous larvae.

(Martin et al., 2005)

Khc¹⁶ shows a posterior paralysis phenotype in larvae in double heterozygous combination with Df(3L)34ex5, Gl¹, E(Khc)ek2^ek2, E(Khc)ek3^ek3, Aplip1^EK4, E(Khc)ek5^ek5, E(Khc)ek6^ek6, E(Khc)ek7^ek7, E(Khc)ek8^ek8, E(Khc)ek9^ek9, E(Khc)ek10^ek10 or Dhc64C^ek1. The number of axonal swellings seen in Khc¹⁶ heterozygotes is dramatically increased if the larvae are also heterozygous for either Df(3L)34ex5, Dhc64C^ek1 or Gl¹. The axon swellings seen in double heterozygotes are rescued by Khc^+t7.5.

(Martin et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Khc¹⁶

(Johnson et al., 2009, Martin et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (5)

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