FlyBase Allele Report: Dmel\Kr-h1[k16802]

General Information

Symbol

Dmel\Kr-h1^k16802

Species

D. melanogaster

Name

FlyBase ID

FBal0087049

Feature type

allele

Associated gene

Dmel\Kr-h1

Associated Insertion(s)

P{lacW}Kr-h1^k16802

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roch et al., 1998, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Kr-h1^k16802

Cytology

Description

Insertion of P{lacW} into the first exon of the more extensive Kr-h1 transcript.

(Pecasse et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,082,716..6,082,716 [+]

(Pecasse et al., 2000, Roch et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Pecasse et al., 2000, Roch et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

The vast majority of homozygous animals show a lethal phenotype before head sac eversion. Occasionally 5 to 6 days after pupariation a red eye colouration is visible within an abnormal head sac of animals which otherwise resemble late prepupae. In most cases necroses appear at one third body length and increase with time.

(Pecasse et al., 2000)

Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement