FlyBase Allele Report: Dmel\Kr-h1[k05905]

General Information

Symbol

Dmel\Kr-h1^k05905

Species

D. melanogaster

Name

FlyBase ID

FBal0087047

Feature type

allele

Associated gene

Dmel\Kr-h1

Associated Insertion(s)

P{lacW}Kr-h1^k05905

Carried in Construct

Also Known As

Kr-h⁶

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roch et al., 1998, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Kr-h1^k05905

Cytology

Description

The P{lacW} insertion is at the 5' end of exon 1 of the Kr-h1α transcript. This allele also contains 6kb deletion 5' to exon 1, removing that exon and most of the first intron.

(Beck et al., 2004)

Insertion of P{lacW} into the first exon of the more extensive Kr-h1 transcript.

(Pecasse et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,083,084..6,083,084 [+]

(Beck et al., 2004, Pecasse et al., 2000, Roch et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | pharate adult stage

(Pecasse et al., 2000)

imaginal disc

(Roch et al., 1998)

Detailed Description

Statement

Reference

18% of homozygotes die during embryogenesis while the rest die during the first larval instar. Kr-h1^k05905/Kr-h1^7.1, Kr-h1^k05905/Kr-h1^7id and Kr-h1^k05905,Kr-h1^k04411 animals die as prepupae.

(Beck et al., 2004)

The vast majority of homozygous animals show a lethal phenotype before head sac eversion. Mutant animals that have undergone head eversion die with the legs and wings apparent and translucent but with hypertrophied eye structures. In most cases necroses appear at one third body length and increase with time.

(Pecasse et al., 2000)

Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities. Heterozygotes are lethal over a Minute chromosome.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions