FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kr-h17.1
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General Information
Symbol
Dmel\Kr-h17.1
Species
D. melanogaster
Name
FlyBase ID
FBal0117712
Feature type
allele
Associated gene
Dmel\Kr-h1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Pecasse et al., 2000)
Progenitor genotype
P{lacW}Kr-h1k04411
(Pecasse et al., 2000)
Kr-h1k04411
(Pecasse et al., 2000)
Caused by aberration
Df(2L)Kr-h17.1
Cytology
Description

Mobilisation of P{lacW}Kr-h1k04411 has caused a deletion that uncovers sequences downstream of the Kr-h1 transcription unit, with a breakpoint close to the original insertion site deleting sequences away from Kr-h1.

(Pecasse et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show apparently normal embryonic development until the first half the first instar larval stage. However mutant complete embryogenesis 2-4 hours later than their heterozygous siblings. As the first instar advances homozygous animals become more and more sluggish in their movements and finally stop moving and their development finally stop in the second half of the first instar. Kr-h17id/Kr-h17.1 and Kr-h17.1/Kr-h1k04411 animals die as late prepupae and show abnormal spiracle positioning.

      (Beck et al., 2004)

      Kr-h1k04411/Kr-h17.1 animals that reached pupariation show a more extreme form of the deformed phenotype seen than in Kr-h1k04411 homozygotes. Aberrant positioning of the anterior spiracles, close to the midline) is occasionally seen in these pupae.

      (Pecasse et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Kr-h17.1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)