FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kr-h1k04411
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General Information
Symbol
Dmel\Kr-h1k04411
Species
D. melanogaster
Name
FlyBase ID
FBal0087046
Feature type
allele
Associated gene
Dmel\Kr-h1
Associated Insertion(s)
P{lacW}Kr-h1k04411
Carried in Construct
Also Known As
Kr-h7
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Roch et al., 1998, BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}Kr-h1k04411
Cytology
Description

The P{lacW} insertion is in exon 1 of the Kr-h1α transcript, and about 1kb upstream of the start of exon 1 of the Kr-h1β transcript.

(Beck et al., 2004)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show an apparently normal embryonic development; however during each of the three larval instars between 12% and 26% of these mutants die, although the majority of the lethality occurs at the end of the pre-pupal stage. These mutants exhibit a characteristic prepupal phenotype, with their anterior spiracles close to the midline. Kr-h17id/Kr-h1k04411, and Kr-h17.1/Kr-h1k04411 animals die as late prepupae and show abnormal spiracle positioning.

      (Beck et al., 2004)

      The central nervous system of Kr-h110642 embryos appears normal.

      (McGovern et al., 2003)

      The vast majority of homozygous animals show a lethal phenotype before head sac eversion. Aberrant positioning of the anterior spiracles, close to the midline) is occasionally seen in these pupae, a phenotype also seen in combination with Kr-h17.1.

      (Pecasse et al., 2000)

      Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities.

      (Roch et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Chromosome carries 2 or more P{lacW} insertions.

      (Roch et al., 1998)

      Lethality id revertable by excision of the P{lacW} element.

      (Beck et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (12)
      Reported As
      Symbol Synonym
      44/11
      (Roch et al., 1998)
      Kr-h1k04411
      (Liu et al., 2018, Jia et al., 2017, Huang et al., 2011)
      Kr-h1k0441
      (Kraut et al., 2001)
      Kr-h1ko4411
      (Wu et al., 2021)
      Kr-h1[7]
      (Kang et al., 2017)
      Kr-h1[k04411]
      (Kang et al., 2017)
      Kr-h7
      (Beck et al., 2004, Pecasse et al., 2000)
      Krh7
      (Long et al., 2025)
      Powk04411
      (BDGP Project Members, 1994-1999)
      l(2)10642k04411
      l(2)44/11
      l(2)k04411
      (Spradling et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)