FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\noi1
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General Information
Symbol
Dmel\noi1
Species
D. melanogaster
Name
FlyBase ID
FBal0088767
Feature type
allele
Associated gene
Dmel\noi
Associated Insertion(s)
P{lacW}noi1
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Meyer et al., 1998)
Mutagen
Delta2-3 transposase
(Meyer et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{lacW}noi1
Cytology
Description

P{lacW} insertion lies 92 nucleotides upstream of the translation initiation codon, in the 5' untranslated region.

(Meyer et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult males have very small testes, they are almost completely devoid of germ cells. Rare spermatocytes and some scarce nonmotile sperm are seen. Females exhibit oogenic defects: block of oogenesis around stage 6 or 7 leading to the accumulation of egg chambers showing several striking defects, or late defects including short and/or flaccid eggs showing fused, short or no dorsal appendage.

      (Meyer et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      noi1 is rescued by noi+t3.6

      (Meyer et al., 1998)
      Comments

      All aspects of the phenotype can be rescued by noi+t3.6.

      (Meyer et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Reversion of the P{lacW} insertion demonstrates it is responsible for the mutant phenotype.

      (Meyer et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      noi1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)