Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Probable component of a the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\noi using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\noi in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: noi l(3)j3E7
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Hypomorphic alleles reveal multiple roles of noi for the survival and differentiation of male germ cells, the differentiation of female germ cells and the development of several adult structures.
Complete loss of noi function results in lethality at the end of embryogenesis, without obvious morphological defects.