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General Information
Symbol
Dmel\IKKε5
Species
D. melanogaster
Name
FlyBase ID
FBal0091354
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G20676854A

Reported nucleotide change:

G?A

Amino acid change:

D160N | IKKepsilon-PB; D160N | IKKepsilon-PC

Reported amino acid change:

D160N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

This mutation is within the putative kinase domain of the expressed protein.

The amino acid replacement, caused by a point mutation, is found in the kinase domain of ik2.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Apoptosis occurs normally in l(2)38Ea36/l(2)38Ea66 and l(2)38Ea46/l(2)38Ea66 embryos.

The tracheal branching of l(2)38Ea66 embryos occurs normally with apparently normal cell number. At stage 17, the terminal branches show a variety of abnormal morphologies. One class of abnormalities is the duplication of terminal cells. The other classes show persistent filopodia formation in the dorsal side of the terminal cells and the ectopic accumulation of F actin dots, as well as the misorientation and bifurcation of the actin core and the terminal branch.

At low temperature and in uncrowded culture conditions, rare escaper ik25 adults (<1%) are observed, but they die shortly after eclosion. These escapers often exhibit abnormal bristles, both the interommatidial and the humeral bristles are affected. At high magnification, the actin footprints along the length of the bristle shaft in ik25 escaper adult eyes appears less organised than those in wild-type bristles. In wild-type, interommatidial bristles are found at alternating vertices, whereas in ik25 mutants these bristles are often duplicated at a single vertex and are misshapen and kinked.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

IKKε5 is a suppressor of eye phenotype of rprGMR.PH

Additional Comments
Genetic Interactions
Statement
Reference

l(2)38Ea66 suppresses the eye ablation phenotype of flies that express rprGMR.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The allele incorrectly referred to as 'ikkε[66]' in FBrf0228877 actually corresponds to IKKε1 (also known as 'ikkε[36]'). The confusion arose due to misannotation of a laboratory stock list.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)