FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shgR6
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General Information
Symbol
Dmel\shgR6
Species
D. melanogaster
Name
FlyBase ID
FBal0092525
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mirkovic and Mlodzik, 2006, Takahashi et al., 2005)
Mutagen
P-element activity
(Godt and Tepass, 1998)
Progenitor genotype
shgk03401
(Godt and Tepass, 1998)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      shgR6 eyes show areas where many ommatidia have rotated less than 90oC.

      (Mirkovic and Mlodzik, 2006)

      The dorsal closure of shgR6 embryos appears normal.

      (Takahashi et al., 2005)

      Homozygous adults have a wing phenotype. shgk03401/shgR6 flies are semi-viable. Border follicle cell migration is substantially delayed in many cases in shgk03401/shgR6 follicles. Approximately 65% of the border cell clusters that have not reached the oocyte at stage 10 are located between nurse cells and only 35% of border cell clusters do not penetrate between nurse cells.

      (Niewiadomska et al., 1999)

      Weak allele. The oocyte is mislocalised in 29.5% of stage 7-9 shgk03401/shgR6 follicles.

      (Godt and Tepass, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      shg[+]/shgR6 is an enhancer of abnormal cell migration phenotype of CskGD9345, Scer\GAL4ptc-559.1

      (Rudrapatna et al., 2014)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      shg[+]/shgR6 is an enhancer of wing disc phenotype of CskGD9345, Scer\GAL4ptc-559.1

      (Rudrapatna et al., 2014)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A shgR6 heterozygous mutant background enhances the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing CskGD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4ptc-559.1.

      (Rudrapatna et al., 2014)

      Unlike either single mutant, shgR6; Src42A6-1 double mutant embryos show a dorsal open phenotype.

      (Takahashi et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      shgR6
      (Rudrapatna et al., 2014, Mirkovic and Mlodzik, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)