FlyBase Allele Report: Dmel\Tcs3[331]

General Information

Symbol

Dmel\Tcs3³³¹

Species

D. melanogaster

Name

FlyBase ID

FBal0092889

Feature type

allele

Associated gene

Dmel\Tcs3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: R145term.

(Lin et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,352,547..16,352,547 [+]

Nucleotide change:

C16352547T

Amino acid change:

R145term | Tcs3-PA

Reported amino acid change:

R145term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lin et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage (with Df(3L)ED220)

(Lin et al., 2015)

decreased body size | larval stage (with Df(3L)ED220)

(Lin et al., 2015)

lethal | recessive

(Bedian, 1998.10.2)

lethal - all die before end of P-stage (with Df(3L)ED220)

(Lin et al., 2015)

melanotic mass phenotype (with Df(3L)ED220)

(Lin et al., 2015)

Phenotype Manifest In

melanotic mass (with Df(3L)ED220)

(Lin et al., 2015)

Detailed Description

Statement

Reference

Compared to wild type (pupate around day 5, eclose around day 10), Tcs3³³¹/Df(3L)ED220 exhibit an extended larval period prior to lethality (viability: 93% at day 8, 50% at day 16) and have melanotic masses ('black spots': 26% at day 8, 58% at day 16); larvae are small and unable to dig into food.

(Lin et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions