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General Information
Symbol
Dmel\Tcs31A2
Species
D. melanogaster
Name
FlyBase ID
FBal0318696
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16352715A

Amino acid change:

D201N | Tcs3-PA

Reported amino acid change:

D201N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: D201N.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Compared to wild type (pupate around day 5, eclose around day 10), Tcs31A2/Df(3L)ED220 exhibit an extended larval period prior to lethality (viability: 97% at day 8, 30% at day 16) and have melanotic masses ('black spots': 50% at day 8, 100% at day 16); larvae are slim.

Compared to control Tcs31A2/+ heterozygote larval hemolymph (made up of primarily plasmatocytes and more rare lamellocytes), Tcs31A2/Df(3L)ED220 hemolymph from second instar larvae shows overrepresentation of lamellocytes; compared to Tcs31A13/Df(3L)ED220, Tcs31A2/Df(3L)ED220 have similar hematopoietic phenotypes but they are weaker and/or slower to develop.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

The Tcs31A2 and Tcs31A19 mutant lines are independent isolations of the same lesion in Tcs3 (amino acid replacement D201N) as they were isolated from different chromosomes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Tcs31A2
Name Synonyms
Secondary FlyBase IDs
    References (1)