FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BxhdpR26
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General Information
Symbol
Dmel\BxhdpR26
Species
D. melanogaster
Name
FlyBase ID
FBal0093476
Feature type
allele
Associated gene
Dmel\Bx
Associated Insertion(s)
Carried in Construct
Also Known As
hdpR26
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Milan et al., 1998)
Mutagen
P-element activity
(Milan et al., 1998)
Progenitor genotype
BxMS1096
(Milan et al., 1998)
Cytology
Description

Imprecise excision of the P{GawB} element.

(Milan et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      BxhdpR26 mutants show increased sensitivity to cocaine.

      (Tsai et al., 2004)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BxhdpR26 adults show decreased circadian rhythmicity and circadian power under constant dark, and lack morning anticipation activity under light-dark cycles, as compared to wild-type controls.

      BxhdpR26 adults show disrupted circadian plasticity of sLNv dorsal projections: while controls exhibit more axon terminal branches at ZT2 than at ZT14 under light-dark cycles or dark conditions, mutants present similar number of axon terminal branches at (presumptive) ZT2 and ZT14, which are similar to ZT14 in controls.

      (Nian et al., 2019)

      Mutant animals exhibit an increased sensitivity to cocaine. Mutant adults exhibit a less robust locomotor rhythm in constant darkness than control flies.

      (Tsai et al., 2004)

      Flies have small wings and show abnormal thickening of the wing veins. The size of the dorsal compartment of the wing disc is reduced compared to wild-type. The Bx1 wing phenotype is completely suppressed in Bx1/BxhdpR26 flies.

      (Milan et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Bx[+]/BxhdpR26 is a suppressor | partially of visible phenotype of mir-9aJ22/mir-9aE39

      (Bejarano et al., 2010)

      Bx[+]/BxhdpR26 is a suppressor of visible phenotype of mir-9aJ22

      (Bejarano et al., 2010)

      Bx[+]/BxhdpR26 is a suppressor of increased cell death phenotype of mir-9aJ22

      (Bejarano et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Bx[+]/BxhdpR26 is a suppressor of wing margin phenotype of mir-9aJ22/mir-9aE39

      (Bejarano et al., 2010)

      Bx[+]/BxhdpR26 is a suppressor of wing margin phenotype of mir-9aJ22

      (Bejarano et al., 2010)

      Bx[+]/BxhdpR26 is a suppressor of wing disc phenotype of mir-9aJ22/mir-9aE39

      (Bejarano et al., 2010)

      Bx[+]/BxhdpR26 is a suppressor | partially of anterior postalar bristle phenotype of mir-9aJ22/mir-9aE39

      (Bejarano et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      BxhdpR26/+ fully rescues the adult wing margin defects of mir-9aJ22 homozygotes and mir-9aJ22/mir-9aE39 animals. BxhdpR26/+ strongly suppresses the ectopic apoptosis seen in the wing discs of mir-9aJ22/mir-9aE39 animals.

      The presence of BxhdpR26/+ partially suppresses the formation of ectopic anterior postalar bristles seen in mir-9aJ22/mir-9aE39 adults, but has only mild effects on the formation of ectopic dorsocentral bristles seen in these flies.

      (Bejarano et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference

      Acute activation of Pdf-positive neurons by expressing TrpA1UAS.(B).cKa under the control of Scer\GAL4Pdf.PU and temperature shift to 30[o]C at ZT12 leads to increased complexity of sLNv dorsal projections at Z14; the same is observed in a BxhdpR26 background.

      (Nian et al., 2019)
      Complementation and Rescue Data
      Comments

      complements: Bx1

      (Milan et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BxhdpR26
      (Nian et al., 2019)
      hdpR26
      (Pueyo and Couso, 2004, Tsai et al., 2004)
      hdpR26
      (Bejarano et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)