FlyBase Allele Report: Dmel\DCP2[tb]

General Information

Symbol

Dmel\DCP2^tb

Species

D. melanogaster

Name

FlyBase ID

FBal0093907

Feature type

allele

Associated gene

Dmel\DCP2

Associated Insertion(s)

gypsy{?'}DCP2^tb

Carried in Construct

Also Known As

DCP2^l(3)tb

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Mishra et al., 2020)

Mutagen

P-element activity

(Roy et al., 1998)

Progenitor genotype

Associated Insertion(s)

gypsy{?'}DCP2^tb

Cytology

Description

A 444bp gypsy LTR-like sequence is inserted in the 5'UTR of DCP2. In addition, intergenic AT-rich sequence between DCP2 and the neighbouring dbo gene is expanded compared to controls. The expression of both DCP2 and dbo is reduced.

(Mishra et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:15,826,410..15,826,410

(Mishra et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with DCP2^BG01766)

(Mishra et al., 2020)

abnormal developmental rate (with DCP2^e00034)

(Mishra et al., 2020)

abnormal developmental rate | recessive

(Mishra et al., 2020)

abnormal eclosion (with DCP2^BG01766)

(Mishra et al., 2020)

abnormal size | third instar larval stage

(Mishra et al., 2020)

decreased cell size | larval stage

(Mishra et al., 2020)

female semi-sterile (with DCP2^BG01766)

(Mishra et al., 2020)

increased body size | P-stage

(Mishra et al., 2020)

increased cell number | larval stage

(Mishra et al., 2020)

increased cell number | larval stage (with DCP2^e00034)

(Mishra et al., 2020)

increased occurrence of cell division | larval stage (with DCP2^e00034)

(Mishra et al., 2020)

increased occurrence of cell division | third instar larval stage

(Mishra et al., 2020)

lethal - all die before end of P-stage | recessive

(Mishra et al., 2020)

lethal - all die before end of pupal stage | recessive

(Roy et al., 1998)

lethal - all die during P-stage (with DCP2^e00034)

(Mishra et al., 2020)

majority die during P-stage (with DCP2^BG01766)

(Mishra et al., 2020)

majority die during P-stage | recessive

(Mishra et al., 2020)

male semi-sterile (with DCP2^BG01766)

(Mishra et al., 2020)

melanotic mass phenotype (with DCP2^BG01766)

(Mishra et al., 2020)

partially lethal - majority die (with DCP2^BG01766)

(Mishra et al., 2020)

some die during pupal stage | recessive

(Roy et al., 1998)

some die during third instar larval stage | recessive

(Mishra et al., 2020)

Phenotype Manifest In

adult abdomen (with DCP2^BG01766)

(Mishra et al., 2020)

adult optic lobe

(Roy et al., 1998)

adult thorax (with DCP2^BG01766)

(Mishra et al., 2020)

embryonic/larval optic lobe | larval stage

(Mishra et al., 2020)

eye disc | third instar larval stage

(Mishra et al., 2020)

interommatidial bristle | absent (with DCP2^BG01766)

(Mishra et al., 2020)

larval brain | larval stage

(Mishra et al., 2020)

larval brain | larval stage (with DCP2^BG01766)

(Mishra et al., 2020)

larval brain | larval stage (with DCP2^e00034)

(Mishra et al., 2020)

larval neuroblast | increased number

(Mishra et al., 2020)

larval neuroblast | increased number (with DCP2^e00034)

(Mishra et al., 2020)

leg (with DCP2^BG01766)

(Mishra et al., 2020)

leg disc | third instar larval stage

(Mishra et al., 2020)

male genitalia (with DCP2^BG01766)

(Mishra et al., 2020)

ommatidium (with DCP2^BG01766)

(Mishra et al., 2020)

wing (with DCP2^BG01766)

(Mishra et al., 2020)

wing disc

(Roy et al., 1998)

wing disc | larval stage

(Mishra et al., 2020)

wing disc | larval stage (with DCP2^BG01766)

(Mishra et al., 2020)

wing disc | larval stage (with DCP2^e00034)

(Mishra et al., 2020)

Detailed Description

Statement

Reference

DCP2^tb homozygotes exhibit bloating and cessation of growth at P-stage.

DCP2^tb homozygous third instar larvae exhibit gross morphological alterations in the size of larval brain, wing, eye and leg discs in the early and late larval phase. They also exhibit an increased occurrence of cell division in larval brains and wing discs; progressive loss of mature neurons in larval brains and eye discs; and an enlargement of leg discs in size. During late larval phase, eye discs exhibit deviations from the usual regular arrangement of ommatidia.

DCP2^tb/DCP2^tb or DCP2^tb/DCP2^e00034 larval brains exhibit increased occurrence of cell division.

DCP2^tb homozygous larvae exhibit an increase in cell number concomitant with a decrease in cell size in wing discs and an increase in cell number in optic lobe.

DCP2^BG01766/DCP2^tb adults exhibit several developmental abnormalities: defects in thorax closure; loss of abdominal para-segments, abdominal bristles and regular arrangement of ommatidia; and presence of abnormal external male genitalia.

(Mishra et al., 2020)

Pupation is delayed and the mutant larvae form pupae but ultimately die. Brain optic lobes are enlarged and the wing imaginal discs show abnormal folding with protrusion of the pouch region. A progressive increase in mitotically active cells with abnormal chromosome condensation is observed with the progression of tumorigenesis.

(Roy et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

DCP2^tb is partially rescued by DCP2^UAS.cRa/Scer\GAL4^Act5C.PI

(Mishra et al., 2020)

DCP2^tb is partially rescued by DCP2^UAS.cRa/Scer\GAL4^Tub.PU

(Mishra et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Isolated as a second-site mutation in a P-element mutagenesis screen.

(Mishra et al., 2020)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DCP2^l(3)tb

(Chaudhary et al., 2025, Mishra et al., 2020)

DCP2^tb

l(3)tb

(Mishra et al., 2020)

l(3)tb¹

Name Synonyms

Secondary FlyBase IDs

References (3)

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