FlyBase Allele Report: Dmel\Abl[K417N.UAS]

General Information

Symbol

Dmel\Abl^K417N.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0095896

Feature type

allele

Associated gene

Dmel\Abl

Associated Insertion(s)

Carried in Construct

P{UAS-Abl.K417N}

Also Known As

UAS-Abl^K417N, UAS-DAbl^K417N, UAS-Abl^KD

Key Links

Transgenic product class

missense_variant

(Fogerty et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Fogerty et al., 1999)

Mutagen

in vitro construct

(Fogerty et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Abl.K417N}

Cytology

Description

A kinase defective form of Abl is expressed under the control of UAS regulatory sequences.

(Fogerty et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Abl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

increased cell number | somatic clone, with Scer\GAL4^wor.PA

(de Torres-Jurado et al., 2022)

visible | adult stage, with Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

eye, with Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

neuroblast | increased number | somatic clone, with Scer\GAL4^wor.PA

(de Torres-Jurado et al., 2022)

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

Detailed Description

Statement

Reference

Expressing Abl^K417N.UAS under the control of Scer\GAL4^GMR.PU induces a very mild rough eye phenotype.

(Bernardoni et al., 2019)

Third instar larvae expressing Abl^K417N.UAS under the control of Scer\GAL4^elav-C155 (but not Scer\GAL4^how-24B) display supernumerary mature and satellite NMJ boutons.

(Kim et al., 2019)

Ectopic expression of Abl^{K417N.Scer\UAS} under the control of Scer\GAL4^ppk.PG does not cause any excessive presynaptic terminal growth and the number of connectives in class IV dendritic arborizing neurons in third instar larvae is the same as in wild-type controls.

(Sterne et al., 2015)

Expression of Abl^{K417N.Scer\UAS}, under the control of Scer\GAL4^P2.4.Pdf, has no effect on LNv morphology.

(Leyssen et al., 2005)

When Abl^{K417N.Scer\UAS} is driven by Scer\GAL4^elav.PLu, no significant defects are seen.

(Bashaw et al., 2000)

Flies expressing Abl^{K417N.Scer\UAS} under the control of Scer\GAL4^hs.2sev have no detectable eye phenotype.

(Fogerty et al., 1999)

ISNb bypass phenotypes are not produced when Abl^{K417N.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PLu.

(Wills et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Abl^K417N.UAS, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^K417N.UAS, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hem^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^K417N.UAS is a suppressor of abnormal neuroanatomy phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

Scer\GAL4³¹/Abl^K417N.UAS is a suppressor | partially of lethal phenotype of Abl¹/Df(3L)st-j7, Nrt^M2

(Fogerty et al., 1999)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Abl^K417N.UAS, Scer\GAL4^elav.PLu has phenotype, non-enhanceable by robo1¹

(Bashaw et al., 2000)

Suppressor of

Statement

Reference

Abl^K417N.UAS, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^K417N.UAS, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hem^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^K417N.UAS, Scer\GAL4^dpp.blk1 is a suppressor of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^WT.UAS

(Xiong et al., 2009)

Abl^K417N.UAS is a suppressor of ventral adult lateral neuron & axon phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hem^{Scer\UAS.T:Myr-Src64B} under the control of Scer\GAL4^GMR.PU is suppressed by co-expression of Abl^{K417N.Scer\UAS}.

(Ku et al., 2009)

Coexpression of Abl^{K417N.Scer\UAS} reduces the efficiency of eya^WT.Scer\UAS to rescue the 'eyeless' phenotype of eya² from 100% to 40%.

(Xiong et al., 2009)

Xenogenetic Interactions

Statement

Reference

Coexpression of Abl^{K417N.Scer\UAS} of with Hsap\APP^{Scer\UAS.T:Hsap\MYC} in the sLNv (both driven by Scer\GAL4^P2.4.Pdf) reduces the extent of sLNv axonal arborization compared to expression of only the Hsap\APP^{Scer\UAS.T:Hsap\MYC} transgene.

(Leyssen et al., 2005)

Complementation and Rescue Data

Partially rescues

Scer\GAL4³¹/Abl^K417N.UAS partially rescues Abl¹/Df(3L)st-j7

(Fogerty et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8566

P{UAS-Abl.K417N}2; Abl¹ e^*/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Abl^{K417N.Scer\UAS}

Abl^K417N.UAS

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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