FlyBase Allele Report: Dmel\elB[EP965]

General Information

Symbol

Dmel\elB^EP965

Species

D. melanogaster

Name

FlyBase ID

FBal0101446

Feature type

allele

Associated gene

Dmel\elB

Associated Insertion(s)

P{EP}elB^EP965

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Progenitor genotype

Associated Insertion(s)

P{EP}elB^EP965

Cytology

Description

P{EP} insertion at position 45828 of DS06238.

(Ashburner et al., 1999.10.12)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:14,409,778..14,409,778 [-]

(Cao et al., 2008, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^en-e16E

(Tseng and Hariharan, 2002)

visible, with Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression using Scer\GAL4^ey.PU does not induce a rough eye phenotype.

(Cao et al., 2008)

Flies expressing elB^EP965 under the control of Scer\GAL4^ap-md544 have a slight thoracic cleft and loss or gain of dorsocentral and scutellar macrochaetae.

(Pena-Rangel et al., 2002)

Expression of elB^EP965 under the control of Scer\GAL4^ey.PH results in eyes that are somewhat reduced in size. Flies expressing elB^EP965 under the control of Scer\GAL4^hs.2sev have wild-type eyes. Flies expressing elB^EP965 under the control of Scer\GAL4^en-e16E have incomplete wing venation.

(Tseng and Hariharan, 2002)

Expression of elB^EP965 under the control of Scer\GAL4^sca-537.4 results in additional scutellar and dorsocentral macrochaetae.

(Abdelilah-Seyfried et al., 2000)

No obvious phenotype.

(Ashburner et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, elB^EP965 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, elB^EP965 has visible phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, elB^EP965 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/elB^EP965 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, elB^EP965 has eye phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Enhancer of

Statement

Reference

elB^EP965/Scer\GAL4^ey.PU is an enhancer of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Scer\GAL4^pnr-MD237/elB^EP965 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

elB^EP965/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, elB^EP965, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, elB^EP965, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing elB^EP965 under the control of Scer\GAL4^pnr-MD237 have strong thoracic and scutellar clefts.

(Pena-Rangel et al., 2002)

Co-expression of CycE^Scer\UAS.cLa suppresses the small eye phenotype caused by expression of elB^EP965 under the control of Scer\GAL4^ey.PH.

(Tseng and Hariharan, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(2)0965

(Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999.10.12)

elB^EP0965

elB^EP965

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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