FlyBase Allele Report: Dmel\Trxr1[G0477]

General Information

Symbol

Dmel\Trxr1^G0477

Species

D. melanogaster

Name

FlyBase ID

FBal0103719

Feature type

allele

Associated gene

Dmel\Trxr1

Associated Insertion(s)

P{lacW}Trxr1^G0477

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.12.2)

Progenitor genotype

Associated Insertion(s)

P{lacW}Trxr1^G0477

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,243,560..8,243,922 [-]

(Missirlis et al., 2002, Peter et al., 2002, Schäfer et al., 1999.12.2)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426770

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal aging | recessive

(Missirlis et al., 2002)

abnormal developmental rate | recessive

(Missirlis et al., 2002)

fertile (with Trxr1^G0481)

(Missirlis et al., 2002)

lethal | female

(Peter et al., 2002)

lethal | recessive

(Missirlis et al., 2002, Schäfer et al., 1999.12.2)

short lived

(Missirlis et al., 2002)

wild-type (with Trxr1^G0481)

(Missirlis et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes spend on average an extra day as third instar larvae compared to wild-type animals. After metamorphosis, only about 2% of pupae eclose. Adults are short lived and only live for a few days.

(Missirlis et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Trxr1^G0481

(Missirlis et al., 2002)

Fails to complement

Trxr1^Δ1

(Missirlis et al., 2002)

Trxr1^Δ2

(Missirlis et al., 2002)

Rescued by

Trxr1^G0477 is rescued by Scer\GAL4^Act5C.PI/Trxr1^mito.UAS

(Missirlis et al., 2002)

Not rescued by

Trxr1^G0477 is not rescued by Trxr1^cyto.UAS/Scer\GAL4^Act5C.PI

(Missirlis et al., 2002)

Comments

Expression of Trxr-1^{mito.Scer\UAS} under the control of Scer\GAL4^Act5C.PI restores the lifespan of Trxr-1^G0477 hemizygous males from a few days up to the range of the wild-type lifespan.

(Missirlis et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

111931

w^67c23 P{lacW}Trxr1^G0477 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.12.2)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426770

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Trxr-1⁴⁷⁷

(Missirlis et al., 2002)

Trxr-1^G0477

Trxr1^G0477

l(1)G0477

(Missirlis et al., 2002, Peter et al., 2002)

l(1)G0477^G0477

(Schäfer et al., 1999.12.2)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close