FlyBase Allele Report: Dmel\Trxr1[Δ1]

General Information

Symbol

Dmel\Trxr1^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0135775

Feature type

allele

Associated gene

Dmel\Trxr1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Missirlis et al., 2002)

Mutagen

P-element activity

(Missirlis et al., 2001)

Delta2-3 transposase

(Missirlis et al., 2002)

Progenitor genotype

Trxr1^G0481

(Missirlis et al., 2001)

Trxr1^G0477

(Missirlis et al., 2002)

Caused by aberration

Df(1)Trxr1^Δ1

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a deletion of open reading frame sequences of exons 3 to 5 common to both Trxr-1 transcripts.

(Missirlis et al., 2002)

About 4kb of DNA has been deleted removing most of the Trxr-1 gene.

(Missirlis et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^E14.UAS

(Dias-Santagata et al., 2007)

modeled by Hsap\MAPT^R406W.UAS

(Dias-Santagata et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Missirlis et al., 2002, Missirlis et al., 2001)

some die during larval stage | recessive

(Missirlis et al., 2002, Missirlis et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Trxr-1^Δ1/+ mutant adult brains do not exhibit neurodegeneration or increased apoptosis of the cortex and neuropil, as compared with controls.

(Dias-Santagata et al., 2007)

Homozygotes hatch and about 70% survive as first instar larvae but die during the second larval instar without any morphologically discernible phenotypes.

(Missirlis et al., 2002)

About 70% of mutant larvae survive to the first instar stage, only to die as second instar larvae without showing morphologically discernable phenotypes.

(Missirlis et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Trxr-1[+]/Trxr1^Δ1 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of increased cell death | adult stage phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Other

Statement

Reference

Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU, Trxr-1[+]/Trxr1^Δ1 has short lived phenotype

(Dias-Santagata et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Trxr-1[+]/Trxr1^Δ1 is an enhancer of adult brain cell body rind phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of neuropil | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of neuron | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of adult brain cell body rind phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of neuropil | adult stage phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Trxr-1[+]/Trxr1^Δ1 is an enhancer of neuron | adult stage phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Trxr-1^Δ1 heterozygotes expressing Hsap\MAPT^E14.Scer\UAS under the control of Scer\GAL4^elav.PU are short lived as compared to controls.

(Dias-Santagata et al., 2007)

Complementation and Rescue Data

Fails to complement

Trxr1^G0477

(Missirlis et al., 2002)

Rescued by

Trxr1^Δ1 is rescued by Trxr1^cyto.UAS/Scer\GAL4^Act5C.PI/Trxr1^mito.UAS

(Missirlis et al., 2002)

Partially rescued by

Trxr1^Δ1 is partially rescued by Scer\GAL4^Act5C.PI/Trxr1^mito.UAS

(Missirlis et al., 2002)

Not rescued by

Trxr1^Δ1 is not rescued by Trxr1^cyto.UAS/Scer\GAL4^Act5C.PI

(Missirlis et al., 2002)

Comments

Expression of Trxr-1^{mito.Scer\UAS} under the control of Scer\GAL4^Act5C.PI partially rescues the pre-adult lethality of Trxr-1^Δ1 flies and also increases the lifespan of the rescued adults to about half that of the lifespan of wild-type flies. Expression of both Trxr-1^{mito.Scer\UAS} and Trxr-1^{cyto.Scer\UAS} under the control of Scer\GAL4^Act5C.PI rescues the lifespan of Trxr-1^Δ1 flies to normal.

(Missirlis et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Trxr-1^Δ-1

Trxr-1^Δ1

Trxr1^Δ1

Trxr^Δ1

(Dias-Santagata et al., 2007)

Name Synonyms

Secondary FlyBase IDs

FBal0126464

References (3)

Report Sections

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