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General Information
Symbol
Dmel\crbIntraY10A.E16A.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0103862
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-crbMyc-PBM
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E16A. Amino acid replacement: Y10A.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4rn-GAL4-5-mediated expression results in neoplastic wing disc overgrowth.

When expression is driven in the eye by Scer\GAL4GMR.PF, adherens junctions do not form ectopically and cell polarity is normal within the photoreceptors.

Over expression of crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC when driven by Scer\GAL4da.G32 produces embryos with an epidermis that develops as a multilayered tissue (unlike the single layered epithelium seen in wild-type embryos).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC rescues the adult eye neurodegeneration phenotype seen in animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU is also significantly suppressed.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC
crbIntraY10A.E16A.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (7)