FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sp1UAS.cSa
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General Information
Symbol
Dmel\Sp1UAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Schock
FlyBase ID
FBal0103959
Feature type
allele
Associated gene
Dmel\Sp1
Associated Insertion(s)
Carried in Construct
P{UAS-Sp1.S}
Also Known As
UAS-Sp1
Key Links
Transgenic product class
wild_type
(Schock et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schock et al., 1999)
Mutagen
in vitro construct
(Schock et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-Sp1.S}
Cytology
Description

UAS regulatory sequences drive expression of Sp1.

(Schock et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sp1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Sp1Scer\UAS.cSa under the control of Scer\GAL4ptc.PU, in combination with gal80[ts] to induce expression from third instar larval stage onwards, leads to defects in joint formation both in prepupal leg discs and in adults, as compared to controls; expression under the control of Scer\GAL4Dll-em212 results in the conversion of the antennal segment 3 and the arista into a leg-like structure.

      (Córdoba et al., 2016)

      Ectopic expression of Sp1Scer\UAS.cSa driven by Scer\GAL4sca-537.4 causes development of mechanosensory stout bristles in ectopic places in the wing, including the posterior margin, veins and intervein regions.

      (Schock et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Sp1UAS.cSa/Scer\GAL4Tub.PU rescues Df(1)btd-Sp1

      (Estella and Mann, 2010)

      Scer\GAL4Dll-em212/Sp1UAS.cSa rescues Df(1)btd-Sp1

      (Estella and Mann, 2010)
      Comments

      Expression of Sp1Scer\UAS.cSa (using the MARCM system under the control of Scer\GAL4tub.PU) fully rescues the growth defects seen in Df(1)btd-Sp1 leg disc clones generated in second instar larvae.

      Expression of Sp1Scer\UAS.cSa significantly rescues the growth defects seen in Df(1)btd-Sp1 mutant leg clones generated in a minute background during embryogenesis using Scer\FLP1Scer\UAS.cUa under the control of Scer\GAL4Dll-em212.

      (Estella and Mann, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sp1Scer\UAS.cSa
      Sp1UAS.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Schock
      (Schock et al., 1999)
      Secondary FlyBase IDs
        References (4)