FlyBase Allele Report: Dmel\Acsl[1]

General Information

Symbol

Dmel\Acsl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0104593

Feature type

allele

Associated gene

Dmel\Acsl

Associated Insertion(s)

Carried in Construct

Also Known As

dAcsl¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Dockendorff et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid numbering based on the 717aa isoform.

(Zhang et al., 2009)

Amino acid replacement: V594D.

(Zhang et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:8,681,167..8,681,167 [+]

Nucleotide change:

T8681167A

Amino acid change:

Reported amino acid change:

V594D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhang et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of non-syndromic X-linked intellectual disability

CEA with Acsl⁰⁵⁸⁴⁷

(Jia et al., 2019)

CEA

(Jia et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic abdominal segment 1

(Zhang et al., 2011)

embryonic abdominal segment 1 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 2

(Zhang et al., 2011)

embryonic abdominal segment 2 (with Df(2R)H3E1)

(Zhang et al., 2011)

embryonic abdominal segment 2 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 3

(Zhang et al., 2011)

embryonic abdominal segment 3 (with Df(2R)H3E1)

(Zhang et al., 2011)

embryonic abdominal segment 3 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 4

(Zhang et al., 2011)

embryonic abdominal segment 4 (with Df(2R)H3E1)

(Zhang et al., 2011)

embryonic abdominal segment 4 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 5

(Zhang et al., 2011)

embryonic abdominal segment 5 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 6

(Zhang et al., 2011)

embryonic abdominal segment 6 (with Df(2R)H3E1)

(Zhang et al., 2011)

embryonic abdominal segment 6 | maternal effect

(Zhang et al., 2011)

embryonic abdominal segment 7

(Zhang et al., 2011)

embryonic abdominal segment 7 (with Df(2R)H3E1)

(Zhang et al., 2011)

embryonic abdominal segment 7 | maternal effect

(Zhang et al., 2011)

Detailed Description

Statement

Reference

About 12% of Acsl¹/Df(2R)H3E1 mutant embryos display segmentation defects such as segment fusion or deletion. The segments A2-A7 are most frequently affected.

Among the Acsl¹ maternal mutant embryos, approximately 11% show partial deletion or fusion of the abdominal segments. Removal of the zygotic contribution enhances the phenotypic percentage to 15%. The segments A1-A7 are most frequently affected.

(Zhang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Acsl¹ has embryonic/larval segmentation phenotype | maternal effect | recessive phenotype, enhanceable by kni[+]/kni¹

(Zhang et al., 2011)

Acsl¹ has embryonic/larval segmentation phenotype | maternal effect | recessive phenotype, enhanceable by Kr[+]/Kr¹

(Zhang et al., 2011)

NOT Enhanced by

Statement

Reference

Acsl¹ has embryonic/larval segmentation phenotype | maternal effect | recessive phenotype, non-enhanceable by hb¹²/hb[+]

(Zhang et al., 2011)

Suppressed by

Statement

Reference

Acsl¹/Acsl⁸ has lethal phenotype, suppressible | partially by Hsap\ACSL4^{UAS.L.Tag:MYC}/Scer\GAL4^Tub.PU

(Zhang et al., 2009)

Acsl¹/Acsl⁸ has lethal phenotype, suppressible | partially by Scer\GAL4^Tub.PU/Hsap\ACSL3^UAS.Tag:MYC

(Zhang et al., 2009)

NOT suppressed by

Statement

Reference

Acsl¹ has embryonic/larval segmentation phenotype | recessive | maternal effect phenotype, non-suppressible by hb¹²/hb[+]

(Zhang et al., 2011)

Acsl¹/Acsl⁸ has lethal phenotype, non-suppressible by Scer\GAL4^Tub.PU/Hsap\ACSL4^{R570S.UAS.L.Tag:MYC}

(Zhang et al., 2009)

Acsl¹/Acsl⁸ has lethal phenotype, non-suppressible by Hsap\ACSL4^{P375L.UAS.L.Tag:MYC}/Scer\GAL4^Tub.PU

(Zhang et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

kni¹/+ significantly increases the fraction of embryos showing segmentation defects caused by maternal mutant homozygous Acsl¹. The segmentation abnormalities become more severe as indicated by more segments being disrupted in each mutant embryo.

Kr¹/+ significantly enhances the percentage of segmentation-impaired embryos caused by maternal mutant homozygous Acsl¹, although the severity is not obviously changed.

hb¹²/+ does not cause any detectable change in the segmentation phenotype of homozygous maternal mutant Acsl¹ embryos.

(Zhang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\ACSL4^{Scer\UAS.L.T:Hsap\MYC} or Hsap\ACSL3^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^tub partially rescues the lethality associated with the Acsl⁸/Acsl¹ genotype.

Expression of Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} or Hsap\ACSL4^{P375L.Scer\UAS.L.T:Hsap\MYC} under the control of Scer\GAL4^tub fails to rescue the lethality associated with the Acsl⁸/Acsl¹ genotype.

(Zhang et al., 2009)

Complementation and Rescue Data

Partially rescued by

Acsl¹/Acsl⁸ is partially rescued by Acsl^{UAS.715.C.Tag:MYC}/Scer\GAL4^Tub.PU

(Zhang et al., 2009)

Comments

Expression of Acsl^{Scer\UAS.715.T:Hsap\MYC.C} under the control of Scer\GAL4^tub partially rescues the lethality associated with the Acsl⁸/Acsl¹ genotype.

(Zhang et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5495

Acsl¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Acsl¹

(Jia et al., 2019)

acsl¹

(Siebert et al., 2015)

dAcsl¹

(Liu et al., 2014, Zhang et al., 2011, Zhang et al., 2009)

l(2)05847¹

l(2)44DEa¹

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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