FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\ACSL4P375L.UAS.L.Tag:MYC
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General Information
Symbol
Hsap\ACSL4P375L.UAS.L.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0242936
Feature type
allele
Associated gene
Hsap\ACSL4
Associated Insertion(s)
Carried in Construct
P{UAS-ACSL4.L.P375L}
Key Links
Transgenic product class
missense_variant
(Zhang et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Zhang et al., 2009)
Mutagen
in vitro construct
(Zhang et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-ACSL4.L.P375L}
Cytology
Description

Amino acid replacement: P375L.

(Zhang et al., 2009)

UAS sequences drive expression of the long form of Hsap\ACSL4 containing a P375L mutation with a C-terminal 6x Tag:MYC tag.

(Zhang et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\ACSL4
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  non-syndromic X-linked intellectual disability
      modeled by Acsl05847, Acsl8
      (Jia et al., 2019)
      modeled by AcslKO
      (Jia et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\ACSL4P375L.Scer\UAS.L.T:Hsap\MYC using Scer\GAL4tub in a Acsl8/+ or wild type background results in a reduction of glial cells along the lamina plexus and in the medulla neuropil, and a reduction in number and the mis-targeting of retinal axons.

      (Zhang et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\ACSL4P375L.Scer\UAS.L.T:Hsap\MYC under the control of Scer\GAL4tub fails to rescue the lethality associated with the Acsl8/Acsl1 and Acsl8/Acsl05847 genotypes.

      Expression of Hsap\ACSL4P375L.Scer\UAS.L.T:Hsap\MYC under the control of Scer\GAL4tub fails to restore neutral lipid staining in Acsl8/Acsl05847 wing discs.

      Expression of Hsap\ACSL4P375L.Scer\UAS.L.T:Hsap\MYC under the control of Scer\GAL4tub fails to restore well-ordered axon projection in the optic lamina of the third instar larval brain of Acsl8/Acslk10313 mutants.

      (Zhang et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ACSL4PL
      (Huang et al., 2016)
      Hsap\ACSL4P375L.Scer\UAS.L.T:Hsap\MYC
      Hsap\ACSL4P375L.UAS.L.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)