FB2026_02 , released June 18, 2026
Allele: Dmel\dosY316F.hs.2sev
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General Information
Symbol
Dmel\dosY316F.hs.2sev
Species
D. melanogaster
Name
FlyBase ID
FBal0104651
Feature type
allele
Associated gene
Dmel\dos
Associated Insertion(s)
Carried in Construct
P{hs-dos.Y316F}
Key Links
Transgenic product class
missense_variant
(Bausenwein et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bausenwein et al., 2000)
Mutagen
in vitro construct
(Bausenwein et al., 2000)
Progenitor genotype
Carried in construct
P{hs-dos.Y316F}
Cytology
Description

A duplicated sev enhancer and Hsp70 promoter drive expression of a mutated dos cDNA in which the predicted Shc protein binding site has been mutated (amino acid replacement Y316F).

(Bausenwein et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
sev
Encoded product / tool
dos
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      dosY316F.hs.2sev rescues dosP115

      (Bausenwein et al., 2000)

      dosY316F.hs.2sev rescues dosR31

      (Bausenwein et al., 2000)
      Comments

      A single copy of dosY316F.hs rescues the lethality of homozygous dosR31 or dosP115.

      (Bausenwein et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dosY316F.hs.2sev
      dosY316F.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)