FlyBase Allele Report: Dmel\dos[P115]

Embryos from homozygous female germline clones show a reduction of posterior Filzkorper and segment A8, as well as mild defects in the anterior head skeleton in 40% of cases. The remaining embryos show no externally visible defects, except a lack of Malpighian tubules.

(Luschnig et al., 2000)

dos^R31/dos^P115 transheterozygotes are lethal. Repeated heat shock induction of P{sE-dos} during development is sufficient to rescue the lethality of dos^R31 and dos^P115 homozygotes and dos^R31/dos^P115 transheterozygotes. Mitotic clones in the eye rarely differentiate photoreceptor cells. In the wing clonal cells are unable to differentiate vein structures. Embryos derived from germline clones exhibit very distinct defects in the terminal structures, they rarely differentiate filzkorper and the abdominal segment A8 is frequently affected and the head skeleton is reduced in size.

(Raabe et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

dos[+]/dos^P115 is a non-enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dos^P115 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

dos[+]/dos^P115 is a non-suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dos^P115 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

dos[+]/dos^P115 is a non-enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dos^P115 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

dos^P115 is a suppressor of photoreceptor cell R7 phenotype of sev^S11.Tag:MYC

(Bausenwein et al., 2000)

dos^P115 is a suppressor of embryonic/first instar larval cuticle phenotype of tor^13D

(Luschnig et al., 2000)

dos^P115 is a suppressor of phenotype of sev^S11.Tag:MYC

(Raabe et al., 1996)

NOT Suppressor of

Statement

Reference

dos[+]/dos^P115 is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dos^P115 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Other

Statement

Reference

Shc^BG, dos^P115 has cephalopharyngeal skeleton | germline clone phenotype

(Luschnig et al., 2000)

Shc^BG, dos^P115 has embryonic abdominal segment 8 | germline clone phenotype

(Luschnig et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

dos^P115 partially suppresses the phenotype of embryos derived from tor^13D/+ females. 85% of embryos derived from dos^P115 Shc^BG double mutant female germline clones lack all structures posterior to segment A7 and have reduced head skeletons. The remaining 15% retain segment A8 but no structures posterior to it. Embryos derived from dos^P115 drk^ΔP24 double mutant female germline clones have a stronger phenotype than embryos derived from either single mutant female germline clone.

(Luschnig et al., 2000)

Fails to suppress the mutant eye phenotype of Ras85D^V12.

(Raabe et al., 1996)

Xenogenetic Interactions

Statement

Reference

The addition of dos::Hsap\GAB1^{hs.T:Avic\GFP} to dos^P115 homozygotes or dos^P115/dos^R31 flies leads to the recovery of fully viable flies.

(Bausenwein et al., 2000)

Complementation and Rescue Data

Rescued by

dos^P115 is rescued by dos^Y631F.mBa

(Bausenwein et al., 2000)