FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pak16
Open Close
General Information
Symbol
Dmel\Pak16
Species
D. melanogaster
Name
FlyBase ID
FBal0117679
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q230term.

    (Newsome et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:6,356,956..6,356,956 [+]
    Nucleotide change:

    C6356956T

    Amino acid change:

    Q230term | Pak-PA; Q230term | Pak-PB; Q230term | Pak-PC; Q230term | Pak-PE; Q230term | Pak-PF; Q230term | Pak-PG; Q230term | Pak-PH; Q230term | Pak-PI; Q230term | Pak-PJ

    Reported amino acid change:

    Q230term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Newsome et al., 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        When somatic clones of Pak16 are induced in the eye-antennal disc, but not the brain (using Scer\FLP1ey.PN), the antennal lobes are severely mis-shapen and aglomerular, and olfactory neuron axons terminate in ectopic locations.

        (Ang et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Pak[+]/Pak16 is a suppressor of abnormal neuroanatomy phenotype of LIMK1UAS.Tag:HA, Scer\GAL4ey-OK107

        (Ng and Luo, 2004)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Pak[+]/Pak16 is an enhancer of phenotype of trioS138606/trio1

        (Newsome et al., 2000)

        Pak[+]/Pak16 is an enhancer of photoreceptor cell & axon phenotype of trioS138606/trio1

        (Newsome et al., 2000)

        Pak[+]/Pak16 is an enhancer of phenotype of trioS138606/trio8

        (Newsome et al., 2000)

        Pak[+]/Pak16 is an enhancer of photoreceptor cell & axon phenotype of trioS138606/trio8

        (Newsome et al., 2000)
        Suppressor of
        Statement
        Reference

        Pak[+]/Pak16 is a suppressor of adult mushroom body phenotype of LIMK1UAS.Tag:HA, Scer\GAL4ey-OK107

        (Ng and Luo, 2004)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The frequency of trioS138606/trio1 or trioS138606/trio8 animals showing defects in photoreceptor axon projection (having a "medulla bypass" phenotype) is enhanced if they are also heterozygous for Pak16.

        (Newsome et al., 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Pak16
        pak16
        (Ihry and Bashirullah, 2014, Sekine et al., 2013, Ng and Luo, 2004)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)