FlyBase Allele Report: Dmel\sax[unspecified]

General Information

Symbol

Dmel\sax^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0118060

Feature type

allele

Associated gene

Dmel\sax

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(McCabe et al., 2004)

Phenotype Manifest In

bouton

(McCabe et al., 2004)

male germline stem cell | germline clone

(Schulz et al., 2004)

synapse

(McCabe et al., 2004)

t-bar

(McCabe et al., 2004)

Detailed Description

Statement

Reference

Packing of inter-ommatidial cells is normal in somatic clones of sax^unspecified homozygous cells in the pupal retina.

(Cordero et al., 2007)

The number of T bars per active zone and bouton surface area per active zone is increased compared to wild type in the boutons of muscle 6/7 in mutant third instar larvae. 70 +/- 4% detachment of the presynaptic membrane is seen. Abnormal "T body" structures are seen in the boutons.

(McCabe et al., 2004)

Marked germ cells derived from homozygous germline stem cell clones are only detected in 15% of testes (in contrast to marked germ cells derived from control clones which are detected in 90-100% of testes). Mutant germ cells derived from homozygous germline stem cell clones develop normally into spermatocytes. Testes with persistent mutant germ cell clones have only one or two cysts of differentiating mutant germ cells (a lower number than in testes with control clones), suggesting that germline stem cell clones homozygous for sax^unspecified may either be lost over time or may divide less frequently than wild-type stem cells.

(Schulz et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

sax^unspecified has embryo phenotype, suppressible by dpp^P6.5

(Xie et al., 1994)

sax^unspecified has embryo phenotype, suppressible by dpp^Sal20

(Xie et al., 1994)

Suppressor of

Statement

Reference

sax^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sax^KG07525

(Dworkin and Gibson, 2006)

sax⁴

(Dworkin and Gibson, 2006)

Rescued by

sax^unspecified is rescued by sax^+t8.9

(Nellen et al., 1994)

Not rescued by

sax^unspecified is not rescued by sax^K291M

(Nellen et al., 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sax^unspecified

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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