FlyBase Allele Report: Dmel\fz[1-1-1.UAS.Tag:MYC]

General Information

Symbol

Dmel\fz^{1-1-1.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0118220

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

P{UAS-fz1-1}

Also Known As

UAS-fz, UAS-fz1-1, UAS-Fz1-1-1, myc-Fz

Key Links

Transgenic product class

cDNA

(Boutros et al., 2000)

wild_type

(Boutros et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Boutros et al., 2000)

wild_type

(Boutros et al., 2000)

Mutagen

in vitro construct

(Boutros et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-fz1-1}

Cytology

Description

UAS sequences drive a fz cDNA that has been tagged with Tag:MYC in the non-conserved region in between the CRD and the transmembrane domains.

(Boutros et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity, with Scer\GAL4^dpp.blk1

(Klein et al., 2006)

abnormal planar polarity, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

abnormal planar polarity, with Scer\GAL4^dpp.blk1

(Wu and Mlodzik, 2008)

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Boutros et al., 2000)

abnormal planar polarity | cell non-autonomous, with Scer\GAL4^dpp.blk1

(Wu et al., 2004)

wild-type, with Scer\GAL4^Dll-md23

(Boutros et al., 2000)

Phenotype Manifest In

eye, with Scer\GAL4^hs.2sev

(Boutros et al., 2000)

mesonotum, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

wing, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

wing hair, with Scer\GAL4^dpp.blk1

(Wu and Mlodzik, 2008, Klein et al., 2006)

wing hair | cell non-autonomous, with Scer\GAL4^dpp.blk1

(Wu et al., 2004)

wing margin, with Scer\GAL4^en-e16E

(Wu et al., 2004)

wing margin bristle, with Scer\GAL4^en-e16E

(Wu et al., 2008)

Detailed Description

Statement

Reference

Expression of fz^{1-1-1.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^nub.PU does not have a wing margin bristle phenotype in adult flies.

(Banerjee et al., 2017)

Expression of fz^{1-1-1.Scer\UAS.T:Hsap\MYC} in a stripe along the antero-posterior wing compartment boundary using Scer\GAL4^dpp.blk1 non-autonomously reorients the wing hairs of neighbouring wild-type cells in adults so that they point away from region of expression. However this effect only occurs when fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is expressed between 14-24 hours after pupal formation (expression was limited to this time period using Scer\GAL80^ts.αTub84B.

(Wu and Mlodzik, 2008)

Wings expressing fz^{1-1-1.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E lack a portion of their margin bristles in the posterior compartment. 27.1% of wings have a large area lacking margin bristles.

(Wu et al., 2008)

Expression of fz^{1-1-1.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1 causes a reorientation of wing hairs relative to the wild-type pattern.

(Klein et al., 2006)

When fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is expressed by Scer\GAL4^dpp.blk1, wing hairs flanking the expression domain point away from it. When fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^en-e16E mild wing notching and mild loss of marginal wing hairs is seen.

(Wu et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz^{1-1-1.UAS.Tag:MYC} has abnormal cell polarity phenotype, enhanceable by Scer\GAL4^dpp.blk1/dco^UAS.cKa

(Klein et al., 2006)

Enhancer of

Statement

Reference

Scer\GAL4^nub.PU/fz^{1-1-1.UAS.Tag:MYC} is an enhancer of visible | adult stage phenotype of meru¹

(Banerjee et al., 2017)

Scer\GAL4^dpp.blk1/fz^{1-1-1.UAS.Tag:MYC} is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^dpp.blk1, dco^UAS.cKa

(Klein et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, fz^{1-1-1.UAS.Tag:MYC} has wing margin bristle phenotype, enhanceable by Scer\GAL4^en-e16E/dgo^UAS.cFa

(Wu et al., 2008)

fz^{1-1-1.UAS.Tag:MYC} has wing hair phenotype, enhanceable by Scer\GAL4^dpp.blk1/dco^UAS.cKa

(Klein et al., 2006)

Scer\GAL4^en-e16E, fz^{1-1-1.UAS.Tag:MYC} has wing margin phenotype, enhanceable by dsh³

(Wu et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, fz^{1-1-1.UAS.Tag:MYC} has wing margin bristle phenotype, suppressible | partially by dgo[+]/dgo³⁰⁸

(Wu et al., 2008)

Scer\GAL4^en-e16E, fz^{1-1-1.UAS.Tag:MYC} has wing margin phenotype, suppressible | partially by dsh^EGFP

(Wu et al., 2004)

Enhancer of

Statement

Reference

Scer\GAL4^nub.PU/fz^{1-1-1.UAS.Tag:MYC} is an enhancer of wing margin bristle phenotype of meru¹

(Banerjee et al., 2017)

Scer\GAL4^dpp.blk1/fz^{1-1-1.UAS.Tag:MYC} is an enhancer of wing margin bristle | increased number phenotype of Scer\GAL4^dpp.blk1, dco^UAS.cKa

(Klein et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The wing margin bristle defects characteristic for meru¹ mutant flies can be exacerbated further by Scer\GAL4^nub.PU-driven expression of fz^{1-1-1.Scer\UAS.T:Hsap\MYC}.

(Banerjee et al., 2017)

Expression of dgo^Scer\UAS.cFa enhances the wing margin bristle loss seen when fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^en-e16E. 70.8% of wings have a large area lacking margin bristles.

One copy of dgo³⁰⁸ partially suppresses the wing margin bristle loss seen when fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^en-e16E. 15% of wings have a large area lacking margin bristles.

(Wu et al., 2008)

Coexpression of fz^{1-1-1.Scer\UAS.T:Hsap\MYC} and dco^Scer\UAS.cKa, under the control of Scer\GAL4^dpp.blk1, results in an enhancement of both the planar cell polarity defects seen when only fz^{1-1-1.Scer\UAS.T:Hsap\MYC} is expressed and an increase number of ectopic wing margin bristles produced relative to when only dco^Scer\UAS.cKa is expressed.

(Klein et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

41791

w^*; P{UAS-fz1-1}3

41792

w^*; P{UAS-fz1-1}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fz^{1-1-1.Scer\UAS.T:Hsap\MYC}

fz^{1-1-1.UAS.Tag:MYC}

fz^{1-1.Scer\UAS.T:Hsap\MYC}

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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