FlyBase Allele Report: Dmel\meru[1]

General Information

Symbol

Dmel\meru¹

Species

D. melanogaster

Name

FlyBase ID

FBal0327215

Feature type

allele

Associated gene

Dmel\meru

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Banerjee et al., 2017)

Mutagen

CRISPR/Cas9

(Banerjee et al., 2017)

Progenitor genotype

Cytology

Description

A deletion of 1585 bp encompassing exons 2, 3 and part of exon 4 (of the RA and RC transcripts) and an insertion of 3 bp.

(Banerjee et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:15,838,460..15,840,044 [-]

Comment:

meru[1] contains a 1585 bp deletion and a 3 base insertion (ACC).

(Holder and Tapon, 2018.1.22)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage

(Banerjee et al., 2017)

visible | adult stage (with Df(3L)BSC575)

(Banerjee et al., 2017)

Phenotype Manifest In

abdominal sternite bristle

(Banerjee et al., 2017)

external sensory organ precursor cell | pupal stage

(Banerjee et al., 2017)

macrochaeta

(Banerjee et al., 2017)

macrochaeta (with Df(3L)BSC575)

(Banerjee et al., 2017)

notal microchaeta

(Banerjee et al., 2017)

wing margin bristle

(Banerjee et al., 2017)

wing margin bristle | increased number (with Df(3L)BSC575)

(Banerjee et al., 2017)

Detailed Description

Statement

Reference

meru¹ as well as meru¹/Df(3L)BSC575 adult mutants show various sensory bristle defects (most frequently wing margin bristle duplication or missing thoracic macrochaetae).

The asymmetric cell division of sensory organ precursor cells is impaired in meru¹ mutant pupae: the asymmetric localization of both pon or baz proteins is perturbed and the division axis is misaligned (relative to the anterior/posterior axis).

(Banerjee et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

meru¹ has visible | adult stage phenotype, enhanceable by baz^NIG.5055R/Scer\GAL4^nub.PU

(Banerjee et al., 2017)

meru¹ has visible | adult stage phenotype, enhanceable by Scer\GAL4^nub.PU/fz^{1-1-1.UAS.Tag:MYC}

(Banerjee et al., 2017)

meru¹ has visible | adult stage phenotype, enhanceable by Scer\GAL4^nub.PU/pins^HMJ21351

(Banerjee et al., 2017)

meru¹ has visible | adult stage phenotype, enhanceable by Scer\GAL4^nub.PU/Gαi^HMS02138

(Banerjee et al., 2017)

meru¹ has visible | adult stage phenotype, enhanceable by dsh¹/dsh¹

(Banerjee et al., 2017)

meru¹ has visible | adult stage phenotype, enhanceable by fz^NIG.17697R/Scer\GAL4^nub.PU

(Banerjee et al., 2017)

Enhancer of

Statement

Reference

meru¹/meru¹ is an enhancer of visible | adult stage phenotype of baz^NIG.5055R

(Banerjee et al., 2017)

meru¹/meru¹ is an enhancer of visible | adult stage phenotype of pins^HMJ21351

(Banerjee et al., 2017)

meru¹/meru¹ is an enhancer of visible | adult stage phenotype of Gαi^HMS02138

(Banerjee et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

meru¹ has wing margin bristle phenotype, enhanceable by baz^NIG.5055R/Scer\GAL4^nub.PU

(Banerjee et al., 2017)

meru¹ has wing margin bristle phenotype, enhanceable by Scer\GAL4^nub.PU/fz^{1-1-1.UAS.Tag:MYC}

(Banerjee et al., 2017)

meru¹ has wing margin bristle phenotype, enhanceable by Scer\GAL4^nub.PU/pins^HMJ21351

(Banerjee et al., 2017)

meru¹ has wing margin bristle phenotype, enhanceable by Scer\GAL4^nub.PU/Gαi^HMS02138

(Banerjee et al., 2017)

meru¹ has wing margin bristle phenotype, enhanceable by dsh¹/dsh¹

(Banerjee et al., 2017)

meru¹ has wing margin bristle phenotype, enhanceable by fz^NIG.17697R/Scer\GAL4^nub.PU

(Banerjee et al., 2017)

Enhancer of

Statement

Reference

meru¹/meru¹ is an enhancer of wing margin bristle phenotype of baz^NIG.5055R

(Banerjee et al., 2017)

meru¹/meru¹ is an enhancer of wing margin bristle phenotype of pins^HMJ21351

(Banerjee et al., 2017)

meru¹/meru¹ is an enhancer of wing margin bristle phenotype of Gαi^HMS02138

(Banerjee et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The wing margin bristle defects observed in meru¹ mutant adults or in flies expressing baz^NIG.5055R or pins^HMJ21351 or Gαi^HMS02138 under the control of Scer\GAL4^nub.PU are mutually enhanceable. The bristle defect of meru¹ mutant flies can be exacerbated further by Scer\GAL4^nub.PU-driven expression of either fz^NIG.17697R or fz^{1-1-1.Scer\UAS.T:Hsap\MYC} (but not arm^Scer\UAS.cWa).

The severity of both the wing margin bristle and the thoracic macrochaetae defects observed in meru¹ or dsh¹ flies are also significantly worsened in the double mutants.

(Banerjee et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

meru¹ is rescued by meru^Ubi-p63E.GFP

(Banerjee et al., 2017)

Comments

The sensory bristle phenotype (duplication of wing margin bristles, missing thoracic macrochaetae) characteristic for meru¹ mutant adults can be rescued by combination with meru^{Ubi-p63E.T:Avic\GFP}.

(Banerjee et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

meru¹

(McLellan et al., 2025, Holder and Tapon, 2018.1.22, Banerjee et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

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