FlyBase Allele Report: Dmel\skd[pap-53]

General Information

Symbol

Dmel\skd^pap-53

Species

D. melanogaster

Name

FlyBase ID

FBal0119165

Feature type

allele

Associated gene

Dmel\skd

Associated Insertion(s)

P{?'lacW}skd^pap-53

Carried in Construct

Also Known As

pap⁵³

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Boube et al., 2000)

Progenitor genotype

skd¹

(Boube et al., 2000)

Associated Insertion(s)

P{?'lacW}skd^pap-53

Cytology

Description

The P{lacW} insertion from skd¹ has undergone an incomplete excision deleting the entire coding portion of exon 1 (amino acids 1-23). Part of the original transposon remains at the insertion site.

(Boube et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Boube et al., 2000)

some die during embryonic stage | recessive

(Boube et al., 2000)

Phenotype Manifest In

embryonic/larval crystal cell

(Milchanowski et al., 2004)

embryonic/larval mouth

(Boube et al., 2000)

maxillary palp | somatic clone

(Boube et al., 2000)

prothoracic leg | distal | somatic clone

(Boube et al., 2000)

sex comb | cell autonomous | ectopic | somatic clone

(Boube et al., 2000)

Detailed Description

Statement

Reference

The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

Homozygous somatic clones induced in the distal second tarsal segment differentiate as ectopic sex comb teeth. This effect appears to be cell autonomous. Clones elsewhere in the T1 leg or at any position in the T2 OR T3 legs are without effect. Homozygous clones in the maxillary palps are associated with malformations. Homozygous clones in the wing blade, the notum, or the antennae lead to apparently normal patterns. Twin spot studies in the larval imaginal wing disc show no apparent affect on size and distribution of homozygous mutant clones.

(Boube et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scr^P, skd^pap-53 has prothoracic leg | distal phenotype, enhanceable by MED17^s2956

(Boube et al., 2000)

Scr^P, skd^pap-53 has sex comb | ectopic phenotype, enhanceable by MED17^s2956

(Boube et al., 2000)

Suppressed by

Statement

Reference

pb^hs.PB, skd^pap-53 has prothoracic leg | distal phenotype, suppressible by Scr⁴

(Boube et al., 2000)

pb^hs.PB, skd^pap-53 has sex comb | ectopic phenotype, suppressible by Scr⁴

(Boube et al., 2000)

Enhancer of

Statement

Reference

skd^pap-53 is an enhancer of prothoracic leg | distal phenotype of pb^hs.PB

(Boube et al., 2000)

skd^pap-53 is an enhancer of sex comb | ectopic phenotype of pb^hs.PB

(Boube et al., 2000)

skd^pap-53 is an enhancer of prothoracic leg | distal phenotype of Scr^P

(Boube et al., 2000)

skd^pap-53 is an enhancer of sex comb | ectopic phenotype of Scr^P

(Boube et al., 2000)

skd^pap-53 is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

skd^pap-53 is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Other

Statement

Reference

MED17^s2956, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, skd^pap-53 has prothoracic leg | distal phenotype

(Boube et al., 2000)

pb^hs.PB, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

pb^hs.PB, skd^pap-53 has prothoracic leg | distal phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P, skd^pap-53 has prothoracic leg | distal phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has unguis | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has tarsal segment | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has prothoracic leg | ectopic phenotype

(Boube et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of skd^pap-53 enhances the ectopic distal sex comb phenotype seen in pb^hs.PB animals. The addition of Scr⁴ to pb^hs.PB, skd^pap-53 flies also suppresses the distal sex comb phenotype. MED17^s2956, Scr^P, skd^pap-53 flies exhibit a stronger ectopic distal sex comb phenotype than any of the double mutant combinations.

(Boube et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pap⁵³

(Milchanowski et al., 2004, Boube et al., 2000, Fernandez-Funez et al., 2000)

skd^pap-53

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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