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General Information
Symbol
Dmel\Su(H)UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Klein
FlyBase ID
FBal0119384
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Su(H)
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of a 2.8kb Su(H) cDNA fragment is governed by UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When Su(H)Scer\UAS.cKa is driven by Scer\GAL4pnr-MD237, an absence of sensory organs in the medial region of the notum is seen.

When Su(H)Scer\UAS.cKa is driven by Scer\GAL4dpp.blk1, a gap or distal deletion is seen in wing vein L3.

Wings from flies expressing Su(H)Scer\UAS.cKa under the control of Scer\GAL4ptc-559.1 have outgrowths in the proximal region of the wing. When the wing disc is examined areas of ectopic growth are seen at the periphery. When Su(H)Scer\UAS.cKa is driven by Scer\GAL4dpp.blk1 the distal L3 wing vein is eliminated.

When expression is driven by Scer\GAL4klu-G410 in a wild type background nearly all neural precursors are lost and derived bristles in the notum and wing margin are consequently missing (although proneural gene expression is initially normal in the discs). When expression is driven by Scer\GAL4ptc-559.1 in a wild type background the wing disc shows an overgrowth phenotype similar to that caused by overexpression of Dl or 'intra' forms of N.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
NOT suppressed by
Other
Additional Comments
Genetic Interactions
Statement
Reference

The addition of freddsRNA.Scer\UAS to Su(H)Scer\UAS.cKa, Su(H)Scer\UAS.cKa animals has no effect on the Su(H)Scer\UAS.cKa phenotype. The cell death phenotype seen in Su(H)Scer\UAS.cKa animals is however, alleviated by Su(H)Scer\UAS.cKa expression.

When Bx42dsRNA.Scer\UAS and Su(H)Scer\UAS.cKa are driven by Scer\GAL4dpp.blk1 a wing overgrowth phenotype is seen.

The addition of N55e11 to Su(H)Scer\UAS.cKa, Scer\GAL4dpp.blk1 or Su(H)Scer\UAS.cKa, Scer\GAL4ptc-559.1 flies leads to a strong enhancement of the wing nicking phenotype. The addition of HScer\UAS.cHa to Su(H)Scer\UAS.cKa, Scer\GAL4dpp.blk1 flies greatly enhances the wing nick phenotype seen in Su(H)Scer\UAS.cKa, Scer\GAL4dpp.blk1 flies alone. The size of the wing is greatly reduced.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

When expression of Su(H)Scer\UAS.cKa is driven by Scer\GAL4dpp.blk1 in a Su(H)2/Su(H)8 mutant the wing pouch size defect is rescued. When expression of Su(H)Scer\UAS.cKa is driven by Scer\GAL4klu-G410 in a Su(H)2/Su(H)8 mutant the neurogenesis and wing pouch size defects are rescued.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Su(H)Scer\UAS.cKa
Su(H)UAS.cKa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Klein
Secondary FlyBase IDs
    References (5)