FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DreddD44
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General Information
Symbol
Dmel\DreddD44
Species
D. melanogaster
Name
FlyBase ID
FBal0120964
Feature type
allele
Associated gene
Dmel\Dredd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Leulier et al., 2000)
Mutagen
ethyl methanesulfonate
(Leulier et al., 2000)
Progenitor genotype
Cytology
Description

In addition to the point mutation reported in FBrf0133276, a second point mutation is present 31bp 'upstream' of the original missense mutation. This second change is a T to A nucleotide change that results a I to N amino acid substitution.

(Leulier, 2019.9.22)

Amino acid replacement: G120R.

(Leulier et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:635,088..635,088 [-]
Nucleotide change:

G635088C

Amino acid change:

G98R | Dredd-PD; G98R | Dredd-PE; G98R | Dredd-PF; G44R | Dredd-PG

Reported amino acid change:

G?R

Comment:

The mutation was originally reported to lead to a G120R amino acid change. That was based on the use of an upstream ATG start codon. Species conservation data and RNA-seq data support the use of a downstream AUG, in which case the amino acid change is predicted to be G98R for the Dredd-RE isoform.

(Leulier, 2019.9.22)
point_mutation
X:635,120..635,120 [-]
Nucleotide change:

T635120A

Reported nucleotide change:

T635119A

Amino acid change:

I87N | Dredd-PD; I87N | Dredd-PE; I87N | Dredd-PF; I33N | Dredd-PG

Reported amino acid change:

I?N

Comment:

The mutation was reported to be an ATT to AAT nucleotide change leading to an Ile to Asn amino achid change. The reported coordinate is one off from the mapped coordinate since the reported coordinate would lead to a silent substitution.

(Leulier, 2019.9.22)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show greatly reduced survival compared to wild type after septic injury with Erwinia carotovora carotovora 15.

      (Meinander et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      DreddD44/DreddD44 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Moreno et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is completely inhibited in a DreddD44/DreddD44 background.

      The small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings is rescued in a DreddD44/DreddD44 background.

      (González and Busturia, 2009)

      Homozygosity for DreddD44 does not supress the ablation of adult eye tissue seen in egrScer\UAS.cMa; Scer\GAL4GMR.PF animals.

      (Moreno et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      D44
      (Leulier, 2019.9.22, Leulier et al., 2000)
      DreddD44
      (Burgmer et al., 2025, Meinander et al., 2012)
      dreddD44
      (González and Busturia, 2009, Moreno et al., 2002)
      dreddΔ44
      (Ferri et al., 2026)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)