FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RYBPUAS.cBa
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General Information
Symbol
Dmel\RYBPUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Bejarano
FlyBase ID
FBal0219380
Feature type
allele
Associated gene
Dmel\RYBP
Associated Insertion(s)
Carried in Construct
P{UAS-RYBP.B}
Also Known As
UAS-dRYBP
Key Links
Transgenic product class
wild_type
(Bejarano et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bejarano et al., 2005)
Mutagen
in vitro construct
(Bejarano et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-RYBP.B}
Cytology
Description

 :Expression of RYBP is under the control of UAS sequences.

(Bejarano et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
RYBP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult abdominal segment 1 | male, with Scer\GAL4arm.PS

      (González et al., 2008)

      adult abdominal segment 4 | male, with Scer\GAL4arm.PS

      (González et al., 2008)

      antennal disc | third instar larval stage, with Scer\GAL4Dll-em212

      (González and Busturia, 2009)

      antennal disc | third instar larval stage, with Scer\GAL4Dll-md23

      (González and Busturia, 2009)

      haltere disc | third instar larval stage, with Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      leg disc | third instar larval stage, with Scer\GAL4Dll-em212

      (González and Busturia, 2009)

      leg disc | third instar larval stage, with Scer\GAL4Dll-md23

      (González and Busturia, 2009)

      mesothoracic leg, with Scer\GAL4arm.PS

      (González et al., 2008)

      metathoracic leg, with Scer\GAL4arm.PS

      (González et al., 2008)

      metathoracic leg, with Scer\GAL4Ubx-lac1-GAL4

      (González et al., 2008)

      postpronotum, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      scutellum, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      scutum, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      sex comb | ectopic, with Scer\GAL4arm.PS

      (González et al., 2008)

      sex comb | ectopic, with Scer\GAL4Ubx-lac1-GAL4

      (González et al., 2008)

      trichome & haltere | ectopic, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      trichome & haltere | ectopic, with Scer\GAL4sd-SG29.1

      (Bejarano et al., 2005)

      trichome of the posterior wing margin, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      triple row of wing sensilla, with Scer\GAL4sd-SG29.1

      (Bejarano et al., 2005)

      wing, with Scer\GAL4sd-SG29.1

      (Bejarano et al., 2005)

      wing, with Scer\GAL4unspecified

      (González and Busturia, 2009)

      wing | ectopic, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      wing disc | third instar larval stage, with Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      wing hair, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)

      wing hair, with Scer\GAL4sd-SG29.1

      (Bejarano et al., 2005)

      wing vein, with Scer\GAL4sd-SG29.1

      (Bejarano et al., 2005)

      wing vein L4, with Scer\GAL4en-e16E

      (Bejarano et al., 2005)
      Detailed Description
      Statement
      Reference

      Overexpression of RYBPScer\UAS.cBa in the third instar wing or haltere disc (using Scer\GAL4nub-AC-62), leg or antenna disc (using Scer\GAL4Dll-em212 or Scer\GAL4Dll-md23) induces apoptotic cell death.

      Scer\GAL4unspecified-mediated expression of RYBPScer\UAS.cBa results in reduced wing size.

      (González and Busturia, 2009)

      Flies expressing RYBPScer\UAS.cBa under the control of Scer\GAL4Ubx-lac1-Gal4 have ectopic sex combs on the metathoracic legs.

      Flies expressing RYBPScer\UAS.cBa under the control of Scer\GAL4arm.PS occasionally have ectopic sex combs on the mesothoracic and metathoracic legs. Males of this genotype have an "Ultra-abdominal" phenotype (long bristles in the A1 segment that are morphologically characteristic of posterior abdominal segments) and a "Miscadestral" phenotype (ectopic pigmentation in the A4 segment).

      (González et al., 2008)

      The wings of RYBPScer\UAS.cBa; Scer\GAL4sd-SG29.1 adults are small and show a range of phenotypes including reduction in the wing size, disruption in the formation of the triple row, malformation of the vein pattern, and trichomes typical of the haltere.

      In RYBPScer\UAS.cBa; Scer\GAL4en-e16E adults, haltere-like trichomes are found in the posterior fo the wing blade, vein 4 is lost and in some cases the poterior row bristles are also lost. Defects in the scutellum suggest transformation towards a more anterior mesonotum fate and a partial ectopic wing is sometimes seen sprouting from the humerus (suggesting some prothracic to mesothoracic transformation).

      The increased size and ectopic bristles seen in Ubxlac1-GAL4/+ are suppressed by RYBPScer\UAS.cBa (Ubxlac1-GAL4 is also a GAL4 driver:Scer\GAL4Ubx-lac1-Gal4), but the resulting halteres have trichomes resembling wing hairs, rather than the small trichomes normally present on halteres. This phenotype is suppressed by Pc3/+.

      (Bejarano et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible | partially by Df(3L)H99/+

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has abnormal size phenotype, suppressible | partially by Df(3L)H99/+

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has abnormal size phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4unspecified

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible by DreddD44/DreddD44

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has abnormal size phenotype, suppressible by DreddD44/DreddD44

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible by FaddRNAi.UASp.SN, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has abnormal size phenotype, suppressible by FaddRNAi.UASp.SN, Scer\GAL4unspecified

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible | partially by trx[+]/trxE2

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has abnormal size phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4unspecified

      (González and Busturia, 2009)
      NOT suppressed by
      Statement
      Reference

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, non-suppressible by Pc3/Pc[+]

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has increased cell death phenotype, non-suppressible by Sce[+]/Sce1

      (González and Busturia, 2009)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      RYBPUAS.cBa, Scer\GAL4sd-SG29.1 has wing phenotype, enhanceable by Pc3/Pc[+]

      (Bejarano et al., 2005)
      Suppressed by
      Statement
      Reference

      RYBPUAS.cBa, Scer\GAL4unspecified has wing phenotype, suppressible | partially by Df(3L)H99/+

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has wing phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4unspecified

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible by DreddD44/DreddD44

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has wing phenotype, suppressible by DreddD44/DreddD44

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible by FaddRNAi.UASp.SN, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has wing phenotype, suppressible by FaddRNAi.UASp.SN, Scer\GAL4unspecified

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible | partially by trx[+]/trxE2

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4nub-AC-62

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4unspecified has wing phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4unspecified

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4nub-AC-62 has wing disc | third instar larval stage phenotype, suppressible | partially by Df(3L)H99/+

      (González and Busturia, 2009)

      RYBPUAS.cBa, Scer\GAL4Ubx-lac1-GAL4, Ubxlac1-GAL4 has haltere phenotype, suppressible by Pc3/Pc[+]

      (Bejarano et al., 2005)

      RYBPUAS.cBa, Scer\GAL4Ubx-lac1-GAL4, Ubxlac1-GAL4 has wing hair | ectopic phenotype, suppressible by Pc3/Pc[+]

      (Bejarano et al., 2005)

      RYBPUAS.cBa, Scer\GAL4Ubx-lac1-GAL4, Ubxlac1-GAL4 has trichome & haltere | ectopic phenotype, suppressible by Pc3/Pc[+]

      (Bejarano et al., 2005)
      NOT suppressed by
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is markedly reduced in a Df(3L)H99/+ background.

      The small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings is partially rescued in a Df(3L)H99/+ background.

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is completely inhibited by coexpression of thScer\UAS.cHa.

      The small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings is rescued by coexpression of thScer\UAS.cHa.

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is completely inhibited in a DreddD44/DreddD44 background.

      The small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings is rescued in a DreddD44/DreddD44 background.

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is completely inhibited by coexpression of FadddsRNA.Scer\UAS.SN.

      The small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings is completely inhibited by coexpression of FadddsRNA.Scer\UAS.SN.

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is diminished in a trxE2/+ background.

      The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is unaffected in a Pc3/+ or Sce1/+ background.

      (González and Busturia, 2009)

      The reduced wing phenotype of RYBPScer\UAS.cBa; Scer\GAL4sd-SG29.1 flies is enhanced by Pc3/+ or pho1/+. In contrast, trxE2/+ largely rescues the wing defects seen in these animals.

      (Bejarano et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of BacA\p35Scer\UAS.cHa suppresses the increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs.

      Co-expression of BacA\p35Scer\UAS.cHa rescues the small wing size seen in Scer\GAL4unspecified RYBPScer\UAS.cBa wings.

      (González and Busturia, 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RYBPScer\UAS.cBa
      RYBPUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Bejarano
      Secondary FlyBase IDs
        References (4)