FlyBase Allele Report: Dmel\Ubx[lac1-GAL4]

General Information

Symbol

Dmel\Ubx^lac1-GAL4

Species

D. melanogaster

Name

FlyBase ID

FBal0175768

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

P{GawB}Ubx^lac1-GAL4

Carried in Construct

Also Known As

Ubx-GAL4, UbxGAL4

Key Links

Allele class

loss of function allele

Mutagen

gene conversion

Nature of the Allele

Allele class

loss of function allele

(Pallavi et al., 2006)

Mutagen

gene conversion

(Pallavi and Shashidhara, 2003)

Progenitor genotype

P{A92}Ubx^lac1

(Pallavi and Shashidhara, 2003)

Associated Insertion(s)

P{GawB}Ubx^lac1-GAL4

Cytology

Description

Replacement of the P{A92} element in P{A92}Ubx^lac1 with a P{GawB} element (using P{GawB}ptc^559.1 as a donor).

(Pallavi and Shashidhara, 2003)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant | homeotic

(Pallavi et al., 2006)

visible | homeotic

(Mohit et al., 2006)

Phenotype Manifest In

capitellum

(Pallavi et al., 2006)

haltere

(Mohit et al., 2006, Bejarano et al., 2005)

macrochaeta | ectopic

(Bejarano et al., 2005)

wing hair | ectopic

(Mohit et al., 2006)

wing margin bristle | ectopic

(Mohit et al., 2006, Pallavi et al., 2006)

Detailed Description

Statement

Reference

The halteres of Ubx^lac1-GAL4/+ flies have some wing-type bristles and trichomes.

(Mohit et al., 2006)

Ubx^lac1-GAL4/+ flies show a haltere-to-wing transformation as the capitellum of the haltere produces between 4 and 7 wing margin-type sensory bristles.

(Pallavi et al., 2006)

Ubx^lac1-GAL4/+ flies have slightly enlarged halteres with a few ectopic bristles.

(Bejarano et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^lac1-GAL4 has visible | homeotic phenotype, enhanceable by Delta^UAS.cHa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has visible | homeotic phenotype, enhanceable by Alh^EP74/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has visible | homeotic phenotype, enhanceable by vn^UAS.cSa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has visible | homeotic phenotype, enhanceable by Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has visible | homeotic phenotype, enhanceable by drl^EP41/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

NOT Enhanced by

Statement

Reference

Ubx^lac1-GAL4 has visible | homeotic phenotype, non-enhanceable by E(spl)m8-HLH^UAS.cGa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Suppressed by

Statement

Reference

Ubx^lac1-GAL4 has visible | homeotic phenotype, suppressible by aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has visible | homeotic phenotype, suppressible by Syx1A^EP28/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^lac1-GAL4 has haltere phenotype, enhanceable by Delta^UAS.cHa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has wing hair | ectopic phenotype, enhanceable by Delta^UAS.cHa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, enhanceable by Delta^UAS.cHa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has capitellum phenotype, enhanceable by vn^UAS.cSa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, enhanceable by vn^UAS.cSa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, enhanceable by Alh^EP74/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has capitellum phenotype, enhanceable by Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, enhanceable by Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has capitellum phenotype, enhanceable by drl^EP41/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, enhanceable by drl^EP41/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has capitellum phenotype, enhanceable by Alh^EP74/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

NOT Enhanced by

Statement

Reference

Ubx^lac1-GAL4 has haltere phenotype, non-enhanceable by E(spl)m8-HLH^UAS.cGa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has wing hair | ectopic phenotype, non-enhanceable by E(spl)m8-HLH^UAS.cGa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, non-enhanceable by E(spl)m8-HLH^UAS.cGa/Scer\GAL4^{Ubx-lac1-GAL4}

(Mohit et al., 2006)

Suppressed by

Statement

Reference

Ubx^lac1-GAL4 has capitellum phenotype, suppressible by aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, suppressible by aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has wing margin bristle | ectopic phenotype, suppressible by Syx1A^EP28/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

Ubx^lac1-GAL4 has capitellum phenotype, suppressible by Syx1A^EP28/Scer\GAL4^{Ubx-lac1-GAL4}

(Pallavi et al., 2006)

RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has trichome & haltere | ectopic phenotype, suppressible by Pc³/Pc[+]

(Bejarano et al., 2005)

Ubx^lac1-GAL4 has macrochaeta | ectopic phenotype, suppressible by RYBP^UAS.cBa/Scer\GAL4^{Ubx-lac1-GAL4}

(Bejarano et al., 2005)

Ubx^lac1-GAL4 has haltere phenotype, suppressible | partially by RYBP^UAS.cBa/Scer\GAL4^{Ubx-lac1-GAL4}

(Bejarano et al., 2005)

RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has haltere phenotype, suppressible by Pc³/Pc[+]

(Bejarano et al., 2005)

RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has wing hair | ectopic phenotype, suppressible by Pc³/Pc[+]

(Bejarano et al., 2005)

Other

Statement

Reference

Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4, vn^UAS.cSa has pigment cell & haltere phenotype

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has pigment cell & haltere phenotype

(Pallavi et al., 2006)

RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has wing hair | ectopic phenotype

(Bejarano et al., 2005)

RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-GAL4}, Ubx^lac1-GAL4 has trichome & haltere | ectopic phenotype

(Bejarano et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Dl^Scer\UAS.cHa in a Ubx^lac1-GAL4 background (the transgene expression is driven by the P{GawB} in the insertion that generates the Ubx^lac1-GAL4 allele) enhances the haltere phenotype of Ubx^lac1-GAL4 flies, leading to a large number of wing-type bristle and trichomes on the haltere. No such enhancement is seen when the E(spl)^Scer\UAS.cGa transgene is expressed.

(Mohit et al., 2006)

Expression of vn^Scer\UAS.cSa results in an enhancement of the haltere-to-wing transformation of Ubx^lac1-GAL4/+ mutants as the capitellum of the halteres produce 30-35 wing margin-type bristles in vn^Scer\UAS.cSa; Ubx^lac1-GAL4/+ flies while there are only 4-7 bristles in Ubx^lac1-GAL4/+ flies. Expression of Egfr^Scer\UAS.cBa also enhances the Ubx^lac1-GAL4 phenotype as Egfr^Scer\UAS.cBa; Ubx^lac1-GAL4/+ flies produce 40-45 wing margin-type bristles on the capitellum. The halteres of Ubx^lac1-GAL4/+ flies expressing either vn^Scer\UAS.cSa or Egfr^Scer\UAS.cBa also show increased pigmentation compared to Ubx^lac1-GAL4/+ or wild-type flies.

Expression of argos^Scer\UAS.cMa completely suppresses the haltere-to-wing transformation of Ubx^lac1-GAL4/+ flies.

Expression of either drl^EP41 or Alh^EP74 results in an enhancement of the Ubx^lac1-GAL4/+ haltere-to-wing transformation phenotype.

Expression of Syx1A^EP28 results in complete suppression of the Ubx^lac1-GAL4/+ haltere-to-wing transformation phenotype.

(Pallavi et al., 2006)

The increased size and ectopic bristles seen in Ubx^lac1-GAL4/+ are suppressed by RYBP^Scer\UAS.cBa (Ubx^lac1-GAL4 is also a GAL4 driver:Scer\GAL4^{Ubx-lac1-Gal4}), but the resulting halteres have trichomes resembling wing hairs, rather than the small trichomes normally present on halteres. This phenotype is suppressed by Pc³/+.

(Bejarano et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ubx¹

(Mohit et al., 2006)

Ubx^lac1-GAL4

Name Synonyms

Secondary FlyBase IDs

References (4)

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